Highly comprehensive and detailed text on best possible sustainable approaches associated with the development, design, and origination of pharmaceuticals Sustainable Approaches in Pharmaceutical Sciences enables readers to understand the best possible green approaches associated with the development, design, and origination of pharmaceuticals, including resources that may minimize the adverse effects associated with synthesis, isolation, and extraction. Sustainable Approaches in Pharmaceutical Sciences covers a myriad of current topics, including mechanochemical improvements for API synthesis, as well as the role of artificial intelligence (AI) in the development and discovery of pharmaceuticals, along with recent developments in hydrogels which respond to triggered factors during topical drug delivery. Authored by experienced scientists from institutions across the world, other sample topics covered in Sustainable Approaches in Pharmaceutical Sciences include: Green technologies and benefits associated with them, white biotechnology, green chemistry, and eco-friendly approaches for designing active pharmaceutical ingredients Impact of sustainable approaches in pharmaceutical industries regarding use of solvents, nanoparticles formulations, and antimicrobial bandages Micro-extractive methods capable of generating high recovery values of the analytes and associated techniques, such as dispersive liquid-liquid microextraction Benefits of the exploration of sustainable chemistry on a commercial scale, particularly in relation to bioresources, chemical manufacturing, and organic transformation Discussing both the foundational science and practicality of different approaches regarding human and environmental health, Sustainable Approaches in Pharmaceutical Sciences is an essential resource for scientists, medical professionals, and industrial professionals working in the fields of sustainable technology and synthesis in pharmaceutical sciences, along with advanced level students.

lgli/Shah K. Sustainable Approaches in Pharmaceutical Sciences_2024.pdf

lgrsnf/Shah K. Sustainable Approaches in Pharmaceutical Sciences_2024.pdf

Shah, Kamal; Chauhan, Durgesh Nandini; Chauhan, Nagendra Singh

Kamal Shah; Durgesh Nandini Chauhan; Nagendra Singh Chauhan

Durgesh Nandini Chauhan, Nagendra Singh Chauhan, Kamal Shah

Wiley & Sons, Incorporated, John

Wiley & Sons, Limited, John

American Geophysical Union

Wiley-Blackwell

United States, United States of America

John Wiley & Sons, Inc., [N.p.], 2023

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Cover
Half Title
Sustainable Approaches in Pharmaceutical Sciences
Copyright
Contents
List of Contributors
Preface
1. Green and Sustainable Approaches in Pharmaceutical Sciences
Contents
1.1 Introduction
1.2 Green Solvents
1.2.1 Water as a Solvent
1.2.2 Ionic Liquids
1.3 Nanoparticle Formulations
1.4 Antimicrobial Bandages
1.5 Green Drug Synthesis
1.5.1 Ibuprofen
1.5.2 Sildenafil
1.5.3 Paroxetine
1.5.4 Quinapril hydrochloride
1.6 Green Nanotechnology
1.7 Benefits of Green Technologies
1.8 White Biotechnology and Green Chemistry
1.9 Conclusion
References
2. Green Approaches in Conventional Drug Synthesis
Contents
2.1 Introduction
2.2 Green Chemistry Perspective
2.3 Green Approaches in Drug Synthesis
2.3.1 Microwave-Assisted Synthesis
2.3.2 Ultrasound-Mediated Synthesis
2.3.3 Molecular Sieving
2.3.4 Milling Approach
2.4 Bio-fabricated Nanoparticles
2.5 Green Approaches in Malaria Treatment
2.6 Green Approaches in Dengue Treatment
2.7 Green Synthesis of Different Drugs
2.7.1 Quinoline-Based Imidazole Derivatives
2.7.2 Benzimidazoles
2.7.3 Chalcone Derivatives
2.8 Conclusion
References
3. Modern Green Extraction Techniques
Contents
3.1 Introduction
3.2 Ecofriendly Sample Preparation Techniques
3.2.1 Solid Phase Extraction
3.2.2 Solid Phase Microextraction
3.2.3 Microextraction by Packet Sorbent
3.2.4 Fabric Phase Sorptive Extraction
3.3 Solvent-Based Microextraction Procedures
3.3.1 Liquid Phase Microextraction
3.3.2 Ionic Liquids and Deep Eutectic Solvents
3.4 Conclusion
References
4. Impact of Green Approaches in Pharmaceutical Industries
Contents
4.1 Introduction
4.2 Metrics for Green Chemistry
4.2.1 Atom Economy (AE)
4.2.2 Mass Intensity/Process Mass Intensity (MI/PMI)
4.2.3 Environmental Factor (E Factor)
4.3 Case Studies of Active Pharmaceutical Ingredients
4.3.1 Ibuprofen
4.3.2 Sildenafil Citrate (Viagra)
4.3.3 Talampanel (LY300164)
4.3.4 Saxagliptin
4.3.5 Pregabalin (Lyrica)
4.4 Solvent Selection Guide
4.5 Barriers to the Adoption of Green Chemistry
4.6 Electronic Lab Notebooks
4.7 Applications of Green Chemistry in the Pharmaceutical Industry
4.7.1 Bioresources
4.7.2 Chemical Manufacturing
4.7.3 Organic Transformations
4.8 Conclusion
Acknowledgements
References
5. Green Analytical Techniques Using Hydrotropy, Mixed Hydrotropy, and Mixed Solvency
Contents
5.1 Introduction
5.2 Green Chemistry
5.3 Hydrotropes and Hydrotropy
5.3.1 Advantages of Hydrotropy
5.3.2 Classification of Hydrotropic Agents
5.3.3 Mechanism of Hydrotropic Solubilisation
5.4 Hydrotropic Technology
5.5 Pharmaceutical Analysis Using Monohydrotropy
5.5.1 Thin-Layer Chromatography
5.5.2 Titrimetric Analysis
5.5.3 Spectrophotometric Analysis
5.5.4 Simultaneous Spectrophotometric Estimation
5.6 Mixed Hydrotropy
5.6.1 Discussion
5.7 Mixed Solvency
5.7.1 Discussion
5.8 Conclusion
References
6. Application of Artificial Intelligence in Drug Design and Development
Contents
6.1 Introduction
6.2 History of Artificial Intelligence
6.3 Artificial Intelligence in the Field of Pharmaceuticals
6.4 Applications of Artificial Intelligence
6.4.1 Drug Target Identification
6.4.2 Molecular Modelling
6.4.3 Pharmacokinetic Optimisation
6.4.4 Dosage Form Design
6.4.5 Drug–Receptor Interaction
6.4.6 Establishing the Probable Mechanism of Action
6.5 Conclusion
References
7. Green Chemistry in the Development of Functionalised Hydrogels as Topical Drug-Delivery Systems
Contents
7.1 Introduction
7.2 Conventional Topical Drug-Delivery Systems
7.3 Hydrogels
7.3.1 Methods of Synthesising Hydrogels
7.3.2 Classification of Hydrogels
7.3.3 Drug-Transport Mechanisms of Hydrogels
7.4 Tailored Hydrogels for Topical Drug Delivery
7.4.1 Thermo-responsive Polymers
7.4.2 Importance of Thermo-responsive Hydrogels in Topical Drug Release
7.5 Adoption of Green Chemistry in Developing Functionalised Hydrogels
7.5.1 Renewable Materials in Synthesising Functionalised Hydrogels
7.5.1.1 Cellulose and Its Derivatives as a Green Polymer for Hydrogel Synthesis
7.5.1.2 Cellulose Hydrogels from Renewable and Sustainable Resources
7.5.1.3 Thermo-Responsive Hydrogels from Natural Polymers for Drug Delivery
7.5.2 Green Chemistry in the Synthesis of Thermo-Responsive Hydrogels
7.5.3 Green Chemistry in Different Preparation Methods
7.5.4 Green Chemistry in Different Thermo-Responsive Polymers
7.6 Conclusion
Acknowledgments
References
8. Advanced Approaches in Green Univariate Spectrophotometric Methods
Contents
8.1 Green Analytical Chemistry Overview
8.2 Strategies for Greening Spectrophotometric Methods
8.2.1 Window 1
8.2.2 Window 2
8.2.3 Window 3
8.2.4 Window 4
8.3 Advanced Ultraviolet Spectrophotometric Methods and Outcomes
8.3.1 Window 1
8.3.1.1 Absorptivity Centring
8.3.1.2 Response Correlation [42]
8.3.1.3 Advanced Balance Point-Spectrum Subtraction via Zero-Order Spectrum [42]
8.3.1.4 Induced Concentration Subtraction [27]
8.3.2 Window 2
8.3.2.1 Advanced Balance Point-Spectrum Subtraction via Derivative Spectrum [42]
8.3.2.2 Relative Absorptivity Distribution via Amplitude at the Isosbestic Point [122]
8.3.3 Window 3
8.3.3.1 Ratio Difference–Isosbestic Points [44]
8.3.3.2 Amplitude Modulation Coupled with Induced Ratio Difference [44]
8.3.3.3 Absorptivity Centring via Factorised Ratio Spectrum [101]
8.3.3.4 Ratio Subtraction Coupled with Unified Constant Subtraction [84]
8.3.3.5 Constant Extraction [123]
8.3.3.6 Advanced Amplitude Centring [124]
8.3.3.6.1 Approach for Partially Overlapping Spectra
8.3.3.6.2 Approach for Completely Overlapping Spectra
8.3.3.7 Dual Amplitude Difference [61]
8.3.3.8 Induced Dual Amplitude Difference Coupled with Spectrum Subtraction [125]
8.3.4 Window 4
8.3.4.1 Unlimited Derivative Ratio [126]
8.3.4.2 Factorised Derivative Ratio Coupled with Spectrum Subtraction [127]
8.3.4.3 Factorised Derivative Ratio Null Contribution [125]
References
9. Cyclodextrin-Based Molecular Inclusion by Grinding
Contents
9.1 Introduction
9.2 Cyclodextrin Inclusion Complex Formation by Grinding
9.3 Mechanisms of Inclusion Complex Formation by Grinding
9.3.1 High-Energy Vibrational Mills
9.3.2 Planetary Mills
9.3.3 Ball Mills
9.3.4 Mortar and Pestle Grinding
9.4 Implementation of Quality by Design in Inclusion Complex Formation by Grinding
9.4.1 Step I: Defining the Quality Attributes, Material Attributes, and Process Parameters/Process Variables
9.4.2 Step II: Prioritizing the Defined Quality Attributes, Process Variables, and Material Attributes as Critical Quality Attributes, Critical Process Variables, and Critical Material Attributes
9.4.3 Step III: Application of Quality Risk Management
9.4.4 Step IV: Involvement of Design of Experiment for Optimisation of Critical Process Variables
9.4.5 Step V: Model Validation and Scale-Up for Commercial Production
9.5 Conclusion
References
10. Synthesis of Graphitic Carbon Nitride Quantum Dots from Bulk Graphitic Carbon Nitride
Contents
10.1 Introduction
10.2 Graphitic Carbon Nitride
10.3 Quantum Dots
10.4 Methods of Synthesis of Graphitic Carbon Nitride Quantum Dots and Their Applications
10.4.1 Top-Down Approaches
10.4.1.1 Chemical Oxidation
10.4.1.2 Ultrasonication
10.4.1.3 Chemical Tailoring
10.4.1.4 Hydrothermal Treatment
10.4.1.5 Electrochemical Oxidation
10.4.2 Other Methods of Synthesis
10.5 Conclusion
References
11. Mechanochemistry for Sustainable Drug Design and Active Pharmaceutical Ingredient Synthesis
Contents
11.1 Introduction
11.2 Mechanochemistry for Sustainable Processes
11.3 Mechanochemistry Apparatus
11.4 Selected Examples of Active Pharmaceutical Ingredient Production Using Mechanochemistry
11.5 Conclusion
Acknowledgement
References
Index

2023-11-10