From New York Times bestselling author Claudia Gray—a summer house party turns into a thrilling whodunit when Mr. Wickham, one of literature’s most notorious rakes, finally gets what's coming to him in this brilliantly imagined murder mystery featuring Jane Austen’s leading literary couples. After many years of happy marriage, Emma Knightley and her husband are throwing a house party, bringing together distant relatives and new acquaintances—not all of whom are well known to the Knightleys but are certainly beloved by every Jane Austen fan: Elizabeth and Fitzwilliam Darcy, Marianne and Colonel Brandon, Anne and Captain Wentworth, and Fanny and Edmund Bertram. Very much not invited is Mr. Wickham, whose latest financial scheme has netted him newfound wealth—and a broadening array of enemies. With his unexpected arrival, tempers flare and secrets are revealed, making it clear that everyone would be happier if Mr. Wickham got his comeuppance. Yet the Knightleys and their guests are all shocked when Wickham turns up murdered—except, of course, for the killer hidden in their midst. With everyone a suspect, it falls to the house party's two youngest guests to solve the mystery of who finally delivered to Wickham his just deserts: Juliet Tilney, the smart and resourceful daughter of Catherine and Henry Tilney, eager for adventure outside Northanger Abbey; and Jonathan Darcy, Elizabeth and Darcy's eldest son, whose adherence to propriety makes his father seem relaxed. In a tantalizing fusion of Austen and Christie, the unlikely pair must put aside their own poor first impressions—and uncover the guilty party before an innocent person is sentenced to hang.

Cake on Tuesday is a profound exploration of leadership, innovation, and personal growth. Drawing from her experience developing Webex Hologram, Elizabeth Bieniek explores the intricacies of innovation and leadership, offering valuable insights for aspiring innovators. Bieniek advocates for the power of disagreement, emphasizing the need for diverse perspectives to foster innovation. She covers topics such as the importance of going outside one's comfort zone and seeking inspiration beyond familiar boundaries. Bieniek encourages readers to embrace curiosity, ask questions, and engage with diverse perspectives to fuel innovation. She reflects on her childhood mantra of "go outside" as a metaphor for venturing beyond conventional thinking. Bieniek also writes about how finding an "angel in the marble" signifies identifying unconventional opportunities and technologies that can disrupt existing norms. Bieniek shares her journey of exploring augmented and virtual...

Based on the revelation and analysis of the social self-consciousness contained in the individual self-consciousness of the meaning of life, the book discusses the human life-world, spiritual world, cultural world and meaning-world. Then, it states the life-world, modes of thought, values ideas, aesthetic consciousness and ultimate concerns of modern humans. It also systematically expounds on the cultivation, the truth, the nurture, the sublimation, the support, the tension and the source of the spiritual home in perspectives of education, science, art, philosophy, theory, mentality and ideals. Constructing a fulfilling spiritual home for man is the realistic meaning of this book.

To elucidate the theoretical underpinnings and practical nuances of China's Outward Foreign Direct Investment (OFDI) in Indonesia spanning 1990-2022, this book intricately integrates its evolutionary trajectory within the framework of both traditional and emerging investment theories. Employing a judicious blend of standardized and empirical approaches, the book employs a comprehensive mix of quantitative and qualitative research methods to provide a nuanced understanding of this dynamic subject matter. Against the backdrop of the post-pandemic era, this book takes the international investment landscape as its context, focusing on Indonesia as the subject of country-specific research. It demonstrates the evolutionary trajectory of China's enterprises' direct investment in Indonesia, synthesizing the structural characteristics of these investments. The study empirically examines the investment effects and their operational mechanisms, determining the multi-dimensional investment distances between the two countries. Additionally, it illustrates the mechanisms underpinning the occurrence of the "liability of foreignness" risks faced by Chinese enterprises and defines the core elements and implementation pathways of the innovative localization investment model.

This book provides a comprehensive overview of the current state of the art in 2D MoS2 materials synthesis, properties, and mimics of various applications. It covers a brief history of MoS2, its origin, properties, and applications in various fields such as optoelectronics, nanoelectronics, catalysis, energy storage and generation, nano-lubricants, etc. The book focuses on novel synthesis approaches of bulk and nano-MoS2. It includes various innovative characterization techniques, different approaches to surface functionalization, strengths, and limitations of these materials along with their different properties. Additionally, it addresses the enhancing the properties of the materials using heterostructure formation with other materials. The topics covered in the book are of vital importance in a wide range of modern and emerging layered materials employed in most industries, academics, healthcare, food, environment, and research institutes. The book brings together numerous experts in the field of MoS2 on novel synthesis, usual properties, and applications of this modern material to address fundamental issues prevailing in this thematic domain. This book is recommended for physics, Chemistry, materials science and engineering departments and as a reference for researchers in the field.

The book focuses on different advanced current control strategies of LC-coupling hybrid active power filter (LC-HAPF) and Thyristor controlled LC-coupling hybrid active power filter (TCLC-HAPF). Both topologies and their corresponding advanced current control strategies are introduced, with more weight placed on the current control strategies. A total of 9 advanced current control strategies are studied in details for both LC-HAPF and TCLC-HAPF. The comprehensive and systematic treatment of advanced current controller design is one of the major features of the book, which is particularly suitable for readers who are interested in learning the design and implementation of current controller design for HAPFs. The book can benefit researchers, engineers, undergraduate and postgraduate students in the fields of electrical and electronic engineering, power electronics, control strategy, etc.

Excerpt from Historical Register of the United States Army: From Its Organization, September 29, 1789, to September 29, 1889 The troop thus provided for were formed into a regiment, conm'sting of 8 companies of Infantry and 2 companies of artillery, under the command of lienl-col. Josiah Harmer. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

The Stellar Legion is a short science fiction story by Leigh Brackett.No one had ever escaped from Venus' dread Stellar Legion. And, as Thekis the low-Martian learned, no one had ever betrayed it - and lived.The Stellar Legion, fighting on Venus against the natives, is quite the opposite of stellar. Rather, they're the dregs of the service, the psychotic, the criminal, the dishonored. But when the young commander Lehn encounters one of his new underlings, MacIan, he senses that something about him is different.MacIan seems like an honorable and brave soldier. Still, when it turns out that someone in their company is a traitor, and it looks like MacIan, Lehn is willing to admit that his instinct might've been wrong. But was he really wrong?The Stellar Legion was first published in Planet Stories magazine in 1940. 5,700 words, reading time approximately 40 min.Leigh Douglass Brackett (1915-1978) was an American author, particularly of science fiction, and has been referred to as the Queen of Space Opera. She was also a screenwriter, known for her work on such films as The Big Sleep (1946), Rio Bravo (1959) and The Long Goodbye (1973). She was the first woman shortlisted for the Hugo Award. [Elib]

Muraly Srinarayanathas's Between Borders, Beyond Boundaries is a compelling narrative that interlaces the personal journey of a seasoned entrepreneur with insightful strategies for global business success. This book is a manual for those who aim to navigate the complexities of international commerce with an authentic, culturally-informed approach. The core of Srinarayanathas's message lies in the EIA method—Embed, Interpret, Act—a transformative process that promises to equip leaders with the skills needed to authentically engage across diverse markets. This method is not just a business strategy; it is a call to integrate the wisdom of local contexts into global ambitions, thereby resonating with the cultural heartbeat of each unique marketplace. Srinarayanathas shares his personal odyssey of cultural immersion—from his early days as a young immigrant in Canada to his experiences in the dynamic business landscapes of South Asia and Europe....

A Highland lass fights for freedom ... only to realize her heart belongs to her captor. Rogue, Book 4One moment Fiona MacLeod is attending a London ball, and the next she's kidnapped and placed in the Dublin Lunatic Asylum by Wesley Alton, a madman who wants revenge on her family. Her one bit of good fortune is that with the women's ward at the asylum overflowing, she's assigned a room in a nearby castle. But the more she tries to deny Alton's cleverly concocted facts, the crazier she sounds to her keeper, the handsome Earl Kier O'Reilly. With his family fortune dwindling, Kier pays his taxes by hosting non-violent asylum inmates in his ancestral castle. He's immediately attracted to Fiona's grey-eyed ethereal beauty, but he sternly reminds himself she's his ward. No matter what his heart whispers and his body screams, he cannot take advantage of a woman who is clinging to the last of her wits. Meanwhile, the MacLeod brothers are hunting for their sister, and woe betide whoever stands in their way. Warning: A beautiful Scottish lass trapped in a nightmare, an Irish earl with a revolutionary secret whose resistance is weakening, an allegedly haunted castle tower, and three braw Highland brothers who refuse to give up hope

This book is a set of best quality peer-reviewed innovative research papers from the International Conference on Signals, Machines, Automation and Algorithm (SIGMAA 2023), held at Shoolini University, India, during 15–16 December 2023 in hybrid mode. This book has originality of work with the innovative ideas regarding artificial intelligence (AI) and its applications in the field of communication, computing, and power technologies.

Foreword Preface Acknowledgments Contents Editors and Contributors About the Editors Contributors 1: An Introduction to the Human Microbiome 1.1 Introduction 1.2 Evolutionary Dynamics and Diversity of the Human Microbiome 1.3 Methods Involved in Human Microbiome Research 1.4 The Human Microbiota in Health and Disease 1.4.1 The Gut Microbiome 1.4.1.1 Gut Microbiota–Xenobiotic Interactions 1.4.2 The Oral Microbiome 1.4.3 The Respiratory Tract Microbiome 1.4.4 The Skin Microbiome 1.4.5 The Urogenital Microbiome 1.4.6 The Placental Microbiome 1.5 The Role of Omics Interplay in Microbiome Research 1.6 Microbiome Engineering for Human Health 1.7 Conclusions and Future Directions References 2: Host–Microbiome Interactions 2.1 Introduction 2.2 The Microbiome at Different Sites of the Human Body 2.2.1 The Skin 2.2.2 The Oral Cavity 2.2.3 The Gastrointestinal (GI) Tract 2.2.4 The Respiratory Tract 2.3 The Role of the Microbiome in Performing Physiological Functions in the Human Body 2.3.1 Metabolism 2.4 Trophic Function 2.4.1 Protective Functions 2.5 Diabetes Mellitus: A Global Metabolic Nightmare 2.6 Regulation of Glucose Homeostasis by the Gut Microbiota 2.7 Host–Microbiome Interactions in Diabetes Mellitus 2.8 Host–Microbiome Interactions in Inflammatory Bowel Disease 2.9 Dysbiosis (Altered Gut Bacteriome) in IBD 2.10 Drug–Microbiome Interactions 2.11 Conclusions References 3: Techniques for Studying the Microbiome 3.1 Introduction 3.2 Metagenomics 3.3 Culture Techniques 3.4 The Role of the Transcriptome in the Exploration of the Human Microbiome 3.5 Techniques for Transcriptomic Analysis 3.6 Transcriptomic Analysis Strategy 3.7 Metaproteomics 3.8 Fluorescence In Situ Hybridization (FISH) for Microbiomes 3.9 Design and Characterization of FISH Probes 3.10 Flow Cytometry 3.11 CARD-FISH 3.12 Nucleic Acid Mimic (NAM)-FISH 3.13 HiPR-FISH 3.14 FISH-NanoSIMS (FISH-Nanoscale Secondary Ion Mass Spectrometry) 3.15 Applications of FISH in Microbiome Research 3.16 Computational Biology Tools for Microbiome Analysis 3.17 Marker Gene Analysis 3.18 Metatranscriptomics, Metabolomics, and Metaproteomics in Microbiome Studies 3.19 Amplicon Analysis 3.20 Functional Analysis 3.21 Artificial Intelligence (AI) and Pictorial Network 3.22 Long-Read Sequencing and Other Advances 3.23 Techniques for Studying Microbiomes from Various Organs 3.24 The Skin Microbiome 3.25 The Oral Cavity Microbiome 3.26 The Respiratory Tract Microbiome 3.27 The Gut Microbiome 3.28 Ex Vivo and In Vivo Sampling to Study the Microbiome 3.29 Fecal Sampling 3.30 Oral Sampling 3.31 Blood Sample 3.32 Endoscopy Samples 3.33 Laser Capture Microdissection (LCM) 3.34 Sampling from Surgery 3.35 Smart Pills/Ingestible Sampling Devices 3.36 Conclusions References 4: Role of Computational Biology in Microbiome Research 4.1 Introduction 4.2 Microbiome and Host Interactions 4.3 Challenges in Microbiome Research 4.3.1 The Complexity and Heterogeneity of Microbiome Data 4.3.2 Limitations of Experimental Techniques 4.3.3 Current Understanding and Knowledge Gaps 4.4 The Role of Computational Biology in Addressing Challenges 4.4.1 Computational Approaches for Microbiome Data Analysis 4.4.1.1 Taxonomic Profiling 4.4.1.2 Functional Annotation 4.4.1.3 Network Analysis 4.4.1.4 Machine Learning Applications 4.4.1.5 Metagenome-Wide Association Studies (MWASs) 4.4.1.6 Longitudinal Data Analysis 4.4.2 Statistical Integration of Multi-Omics Data 4.4.2.1 Challenges in Integrative Analysis 4.4.2.2 Statistical Approaches for Integration 4.4.2.3 Case Studies in Integrative Analysis 4.5 Personalized Medicine and Patient Stratification 4.5.1 Microbiome-Based Patient Stratification 4.5.2 Implications for Disease Management and Treatment 4.5.2.1 Predictive Biomarkers for Disease Progression and Severity 4.5.2.2 Personalized Treatment Strategies 4.5.2.3 Fecal Microbiota Transplantation (FMT) for Disease Treatment 4.5.2.4 Microbiome-Targeted Therapeutics 4.6 Future Directions and Challenges 4.6.1 Emerging Technologies and Computational Innovations 4.6.1.1 Single-Cell Sequencing and Microbiome Research 4.6.1.2 Artificial Intelligence (AI) and Machine Learning in Microbiome Research 4.6.2 Advancing Data Integration and Analysis Pipelines 4.6.3 Ethical Considerations and Data Sharing 4.6.3.1 Informed Consent and Data Privacy 4.6.3.2 Data Sharing and Collaboration 4.7 Bioinformatics and Its Role in Microbiome Research 4.8 Conclusions References 5: The Epigenetic Impact of the Human Microbiota on Host Cells 5.1 Introduction 5.2 The Human Microbiota and Its Compartments 5.3 The GM and Its Involvement in Disease 5.4 Introduction into Epigenetic Changes 5.5 An Epigenetic Crosstalk Between the Intestinal Microbiome and Host Cells 5.5.1 The GM Modulates All Three Major Types of Epigenetic Changes in Human Cells 5.5.2 Host Cells Also Signal to the Intestinal Microbiome 5.5.3 SCFAs in the Large Intestine 5.5.4 SCFA Effects on Colonocytes and Undifferentiated Cells 5.5.5 SCFA Effects on Immune Cells 5.6 The Gut–Brain Axis 5.7 The Gut–Lung Axis and the Respiratory Tract (RT) Microbiota 5.8 The Gut–Skin Axis and the Skin Microbiota 5.9 Epigenetic Effects of the GM on Other Tissues 5.10 The Vaginal Microbiota 5.11 Conclusions References 6: Unraveling the Complexity of the Skin Microbiome: Advancing Research Through Optimal Biological Models 6.1 Introduction 6.2 Dynamic Interactions Between Human Microbes and Surrounding Environment 6.3 Delineation Differentiation of Microbial Communities in Humans 6.4 The Skin Microbiome 6.5 Habitat of the Skin 6.6 Microbiological Investigation of Skin Microbiota 6.6.1 Variation by Skin Site 6.6.2 Temporal Variation 6.6.3 Interpersonal Variation 6.7 Microbial Community Structure of Human Skin 6.8 Skin Microbial Diversity and Plasticity 6.9 Skin Microbiota–Immunity Dialog 6.10 Control of Adaptive Immunity by the Skin Commensals 6.11 Potential Association of the Microbiota with Skin Inflammatory Disorders 6.12 The Role of Skin in Protective Immunity and Chronic Immune-Mediated Inflammatory Disease 6.12.1 Skin Microbiota and Innate Immunity 6.12.2 Skin Microbiota and Adaptive Immunity 6.12.3 Atopic Dermatitis 6.12.4 Psoriasis 6.13 Skin Microbiome and Acne 6.13.1 Overview 6.13.2 Propionibacterium acnes and Acne 6.14 Acne Pathogenesis 6.14.1 Increasing Sebum Secretion 6.14.2 Promoting Comedone Formation 6.14.3 Inducing/Aggravating Inflammation 6.15 Malassezia and Acne 6.16 Antibiotics in Acne Treatment 6.17 Extrinsic Factors Shaping Skin Microbiome 6.17.1 Early Life Exposures 6.17.2 Cosmetics 6.17.3 Environment and Nature 6.17.4 Antimicrobial Agents 6.17.5 Bacterium-Based Agents 6.18 Skin Microbiota and Host Interactions 6.18.1 Host–Mutualist Interactions 6.18.2 Host–Pathogen Interactions 6.18.3 Contingental Pathogenicity 6.19 Skin Metagenomics 6.19.1 Cultivation Approach 6.19.2 Accessing the Skin Microbiome 6.19.3 Taxonomic Characterization of Skin Microbiome 6.19.4 Output of Metagenomic-Based Taxonomic Inventory of Human Skin 6.19.5 Functional Characterization of Skin Microbiome 6.20 Microbiome Dysbiosis 6.21 Strategies for the Skin Microbiome Research 6.22 Conclusion References 7: Oral Microbiome and Its Implication on Systemic Diseases 7.1 Introduction 7.1.1 Composition of Oral Microbiota 7.1.1.1 Bacterial Components 7.1.1.2 Viral Components 7.1.1.3 Fungal Components 7.1.1.4 Protozoal Components 7.1.1.5 Archaeal Components 7.1.2 Development of Oral Biofilm 7.1.2.1 Architecture of Supragingival Biofilm 7.1.2.2 Architecture of Subgingival Biofilm 7.1.2.3 Architecture of the Biofilm on the Dorsum of the Tongue 7.1.3 Oral Dysbiosis and Associated Oral Diseases 7.1.3.1 Dental Caries 7.1.3.2 Endodontic Infections 7.1.3.3 Periodontal Infections 7.1.3.4 Oral Cancer Release of Inflammatory Mediators Modulation of Apoptotic Activity Production of Carcinogenic Substances 7.1.4 Importance of Oral Microbiome in Systemic Health 7.1.5 Oral Microbiome Influence on the Systemic Diseases in Human 7.1.5.1 Oral Microbiome on Cardiovascular Diseases (CVDs) 7.1.5.2 Oral Microbiome on Gastrointestinal Disease 7.1.5.3 Oral Microbiome on Diabetes Mellitus 7.1.5.4 Oral Microbiome on Rheumatoid Arthritis 7.1.5.5 Oral Microbiome on Pregnancy Complications 7.1.5.6 Oral Microbiome on Alzheimer’s disease 7.2 Conclusion and Perspectives References 8: Microbiome and Reproductive Health 8.1 Introduction 8.2 Reproductive Disorders Associated with Microbial Dysbiosis 8.2.1 Bacterial Vaginosis 8.2.2 Endometrial Cancer 8.2.3 Polycystic Ovary Syndrome 8.2.4 Prostate Cancer 8.2.5 Endometriosis 8.2.6 Vulvovaginal Candidiasis 8.2.7 Sexually Transmitted Diseases (STDs) 8.3 Microbiome-Based Interventions 8.3.1 Cervicovaginal Microbiota Treatment (Probiotics and Hormonal Therapy) 8.3.2 Treatment of Vulvovaginal Infections by Prebiotics and Probiotics 8.3.3 Fecal Microbiota Transplantation and Vaginal Atrophy 8.3.4 Vaginal Microbiome Transplantation 8.4 Conclusions References 9: Microbiome and Neurological Disorders 9.1 Introduction 9.2 Influence of Microbiota in Neurodevelopmental Disorders 9.2.1 Autism Spectrum Disorders (ASDs) 9.2.2 Schizophrenia 9.2.3 Parkinson’s Disease (PD) 9.2.4 Multiple Sclerosis (MS) 9.2.5 Neuromyelitis Optica (NMO) 9.2.6 Amyotrophic Lateral Sclerosis 9.2.7 Alzheimer’s Disease (AD) 9.2.8 Gliomas 9.2.9 Epilepsy (EPY) 9.2.10 Stroke and Brain Injury 9.3 Synergistic Connection and Reciprocal Modulation Between the Microbiota and the Immune System (IS) 9.3.1 Inflammasome-Associated Signaling Cascade 9.3.2 NF-κB-Mediated Signaling Cascade 9.3.3 Intracellular Signaling Cascade Associated with Type I Interferons (IFN-1) 9.3.4 ENS–Central Nervous System Communication 9.4 Microbiome-Based Interventions for Managing or Preventing Neurological Disorders 9.4.1 Probiotics 9.4.2 Prebiotics 9.4.3 Fecal Microbiota Transplantation (FMT) 9.4.4 Antibiotics and Microbiota-Targeted Therapies 9.4.5 Postbiotics 9.5 Conclusions References 10: Microbiome and Circadian Rhythms: Implications for Sleep, Aging, and Therapeutic Strategies 10.1 Introduction 10.2 Human Gut-Microbiome 10.3 Circadian Rhythm 10.3.1 Central Clock 10.3.2 Peripheral Clock 10.4 Hypothalamus–Pituitary–Adrenal Axis (HPA Axis) 10.5 Vagus Nerve Pathway 10.6 The Microbiota–Gut–Brain Axis 10.6.1 Communication from Gut-microbiota to Brain 10.6.2 Communication from Brain to Gut-microbiota 10.7 Short Chain Fatty Acids (SCFAs) and their Mode of Action 10.8 Interface of Human Gut-microbiome and Circadian Rhythm 10.9 Gut-microbiota, Circadian Rhythm and Sleep Associated Disorder 10.10 Gut Microbiome, Circadian Rhythm, and Aging 10.11 Bmal1, IgA, and AD 10.12 Therapeutic Strategies 10.12.1 Probiotics 10.12.2 Melatonin Supplemenation 10.12.3 Antibiotics 10.12.4 Diet 10.12.5 Post-Biotics 10.13 Conclusion References 11: Microbiome-Based Therapeutics in Immunological Disorders 11.1 Introduction 11.2 Microbiome and the Immune System 11.3 Evolution of Gut Microbiome and Immune System 11.4 Interaction of Gut Microbiota with Immune System 11.5 Implications of Dysbiosis and Altered Microbiome Diversity on Immunological Disorders 11.5.1 Impact of Dysbiosis on Immune System 11.5.2 Gut Dysbiosis 11.5.3 Gut Dysbiosis in Inflammatory Bowel Disease 11.6 Role of Microbiome in Modulating Immune Response 11.6.1 Modulation of Vaginal Microbiome 11.6.2 Gut Microbiome Modulation 11.7 Microbiome-Based Therapeutics 11.7.1 Probiotics and the Immune System 11.7.2 FMT and the Immune System 11.7.3 Mechanisms of FMT and Probiotics 11.7.4 Prebiotics and Immune System 11.8 Efficacy and Safety of Probiotics and FMT in Clinical Practice 11.9 Conclusions References 12: Microbiome-Based Treatment for Gastrointestinal Tract Disorders 12.1 Introduction 12.2 The Gut-Brain Link 12.3 The Rationale for Using Microbiome-Based Treatments 12.4 Clostridium Difficile Infection (CDI) 12.5 Complicated and/or Severe Clostridium Difficile Infection 12.6 Inflammatory Bowel Disease (IBD) 12.7 Irritable Bowel Syndrome (IBS) 12.8 Metabolic Syndrome (MS) 12.9 Diabetes Mellitus 12.10 Non-Alcoholic Fatty Liver Disease (NAFLD) 12.11 Cancer 12.12 Conclusion References 13: Microbiome-Targeted Therapies: Enhancing Resilience in Metabolic Disorders 13.1 Introduction 13.2 Development and Composition of Normal Gut Microbiota 13.3 Role of Gut Microbiota in Metabolic Disorders 13.3.1 Gut Microbiota and Glucose Metabolism 13.3.2 Gut Microbiota in Type 2 Diabetes Mellitus 13.3.3 Gut Dysbiosis in Obesity 13.4 An Overview of the Gut Microbiome in CMD Perspective 13.4.1 Metabolic Disease, Gut Microbiome, and Bile Acid Interplay 13.4.2 Insulin Resistance and Microbial Factors 13.5 Skeletal Muscle 13.6 Liver 13.6.1 Adipose Tissue 13.7 Brown Adipose Tissue and Whole-Body Energy Expenditure 13.8 Intestine 13.9 New Approaches to Microbiome-Based Therapies 13.9.1 Microbiome-Based Therapies 13.9.2 Metabolite-Based Therapeutics as Attractive Alternative Treatments for Dysbiosis 13.9.3 Coevolution of Intestinal Microbes and the Host 13.10 Challenges in the Translation of Microbiome Research into Clinical Practice 13.11 Conclusion References 14: Microbiome-Based Therapeutics for the Management of Cancer 14.1 Introduction 14.2 Human Gut Microbiome 14.3 Gut Microbiota Role in Treating Tumor 14.3.1 Improved Anticancer Drug Efficacy by Microbes 14.4 Role of Pathogenic Microbes in the Development of Cancer 14.5 Gut-MBM Role in the Treatment of Cancer 14.5.1 Fecal Microbiome Transplantation 14.5.2 Probiotics 14.5.3 Designer Microbial Consortia and Next-Generation Biotherapeutics 14.5.4 Diet, Prebiotics, and Postbioptic 14.5.5 Targeted Modulation 14.5.6 Targeting the Microbiota of Tumors 14.6 Conclusion and Future Implications References 15: Microbiome-Based Therapies for Mental Health Disorders 15.1 Introduction 15.2 Human Microbiome 15.3 The Gut-Brain Axis 15.4 Microbial Metabolites and Postbiotics 15.5 Fermented Foods 15.6 Microbiome Dysbiosis and Mental Health 15.6.1 The Gut Microbiome’s Role in Anxiety 15.6.2 The Role of the Gut Microbiome in Depression 15.6.3 The Role of the Gut Microbiome in Autism 15.6.4 The Role of the Gut Microbiome in Schizophrenia 15.7 Mechanisms of CNS Effect on the Microbiota 15.8 Microbiome-Based Therapies 15.9 Significance of Microbiome-Based Therapies 15.10 Microbiome-Based Therapies for Mental Health Disorders 15.10.1 Probiotics 15.10.2 Effect of Probiotics on Hypothalamic–Pituitary–Adrenal (HPA) Axis 15.10.3 Effect of Probiotics on Neurotransmitters 15.10.4 Effect of Probiotics on Inflammation: 15.10.5 Prebiotics 15.10.6 Effect of Prebiotics on Anxiety 15.10.7 Effects of Prebiotics on Depression 15.10.8 Effects of Prebiotics on Stress 15.10.9 Fecal Microbiota Transplant 15.11 Constraints in Microbiome-Based Therapies for Mental Health Disorders 15.12 Ethical Concerns 15.13 Conclusion and Future Perspectives References 16: Transforming Infection Treatment with Microbiome-Based Therapeutics 16.1 Introduction 16.2 Human Microbe and Disease 16.2.1 Cancer 16.2.2 Cardiovascular Diseases 16.2.3 Inflammatory Bowel Disease 16.2.4 Bacterial Translocation and Systemic Diseases 16.3 Therapeutic Approaches Based on the Microbiome 16.3.1 Prebiotics 16.3.2 Probiotics 16.3.3 Facel Microbiota Transplantation 16.3.4 Postbiotics 16.3.5 Live Bio-therapeutics 16.4 Microbiome and Probiotic Antiviral Mechanisms 16.5 The Antifungal Impact of Beneficial Bacteria 16.6 Innovative Microbiome Engineering Framework 16.6.1 In Situ Engineering 16.6.2 Targeted Genetic Engineering Using Metabolic Modelling 16.7 Conclusion References 17: Microbiome-Based Formulations and Products and Their Therapeutic Implications 17.1 Introduction 17.2 Modulation of Microbiome 17.2.1 Dietary Interventions 17.2.1.1 Specific Carbohydrate Diet (SCD) 17.2.1.2 Exclusive Enteral Nutrition (EEN) 17.2.1.3 FODMAPs (Fermentable Oligo-, Di-, and Monosaccharides, and Polyols) Diet 17.2.2 Prebiotics 17.2.3 Probiotics 17.2.3.1 Antibiotics 17.2.4 FMT 17.2.5 Phage Therapy 17.2.6 Live Biotherapeutics 17.2.7 Microbiome Mimetics 17.3 Microbiome-Based Metabolite Treatment 17.4 Major Function of Microbial Products 17.5 Metabolite-Based Therapy 17.6 Challenges in Metabolite Treatment Based on the Microbiome 17.7 Challenges and Future Aspects of Microbiome-Based Products and Formulations for Therapeutic Uses 17.8 Challenges in the Field of Microbiome Therapeutics 17.9 Future Aspects of Microbiome-Based Product and Formulations or Therapeutics Uses 17.10 Conclusion References 18: Strategies for Modulating the Gut Microbiome 18.1 Introduction 18.2 Composition and Development of Gut Microbiome 18.3 Beneficial Roles of Gut Microbiota 18.3.1 Role of Gut Microbiome in Immunity 18.3.2 Role of Gut Microbiome in GALT Formation and Inducing Mucosal Immunity 18.3.3 Importance of Gut-Microbiota-Generated SCFA 18.3.3.1 SCFA Formation 18.3.3.2 Benefits of SCFAs 18.3.4 Vitamin Synthesis by Gut Microbes 18.4 Microbial Dysbiosis in Gut 18.5 Strategies for Modulating Gut Microbiome 18.5.1 Modulation of Gut Microbiome by Dietary Interventions 18.5.1.1 Polyphenols 18.5.1.2 Carbohydrates 18.5.1.3 Vitamins 18.5.1.4 Fats 18.5.1.5 Proteins 18.5.2 Probiotics 18.5.2.1 Immunomodulatory Role of Probiotics 18.5.2.2 The Role of Particular Probiotics in Balancing the F/B Ratio 18.5.3 Prebiotics 18.5.3.1 Synthesis of Fermentation Metabolites 18.5.3.2 Direct Effect of Prebiotics 18.5.4 Synbiotics 18.5.5 Postbiotics 18.5.6 FMT 18.6 Conclusion 18.7 Future Perspective References 19: Modulating the Human Microbiome: The Impact of Xenobiotics on Gut Microbial Composition and Therapeutic Strategies 19.1 Introduction 19.2 The Impact of Xenobiotics on Gut Microbial Composition 19.2.1 Bisphenols and Gut Microbiome 19.2.2 Phalates and Gut Microbiome 19.2.3 Persistent Organic Polutants and Gut Microbiome 19.2.3.1 Polychlorinated Biphenyls 19.2.3.2 Polycyclic Aromatic Hydrocarbons 19.2.3.3 Perfluoroalkylated and Polyfluoroalkylated Substances 19.2.3.4 Polybrominated Diphenyl Ethers 19.2.3.5 Polychlorinated Dibenzo-p-Dioxins 19.2.4 Pesticides and Gut Microbiome 19.2.5 Heavy Metals and Gut Microbiome 19.3 Potential Therapeutic Strategies for Modulating Disturbed Gut Microbiota 19.3.1 Fecal Microbiota Transplantation 19.3.1.1 Application of FMT in the Treatment of Intestinal Disorders 19.3.1.2 Application of FMT in the Treatment of Extraintestinal Disorders 19.3.1.3 Donor Selection 19.3.1.4 Sample Handling 19.3.1.5 Methods of Application 19.3.1.6 Future Persepectives in Fecal Microbiota Transplatation 19.3.2 Probiotics and Prebiotics 19.3.3 Microbiome and Diet 19.3.4 Microbiome and Lifestyle References 20: Building a Better Microbiome: Advances in Microbiome Engineering for Human Health 20.1 Introduction 20.2 Microbiome Engineering Strategies 20.3 Transforming Microbiome Population Patterns 20.4 Increasing the Microbiome Diversity 20.5 Probiotic Supplementation 20.6 Prebiotic Supplementation 20.7 Depletion of Particular Microbiome Members 20.8 Alteration of Microbiome Functionality 20.9 DNA Conjugation-Mediated Engineering 20.10 Impact of Enzyme Inhibitors 20.11 Modulation of Microbiota Metabolite Through Engineered Microbes 20.12 Synthetic and Natural Microbial Consortia 20.13 Fecal Microbiota Transplantation 20.14 Synthetic Microbial Consortia 20.15 Current Challenges and Limitations of Microbiome Engineering 20.16 Conclusion References 21: Regulatory Considerations for Microbiome-Based Therapeutics 21.1 Introduction 21.2 Overview of Regulatory Authorities of Microbiome-Based Therapeutics 21.2.1 Food and Drug Administration (FDA) 21.2.2 European Medicines Agency (EMA) 21.2.3 Health Canada 21.2.4 Pharmaceuticals and Medical Devices Agency (PMDA) 21.2.5 Therapeutic Goods Administration (TGA) 21.2.6 National Medical Products Administration (NMPA) 21.3 Microbiome-Based Therapeutics 21.3.1 Probiotics 21.3.2 Prebiotics 21.3.3 Postbiotics 21.3.4 Drug Regulation 21.3.5 Fecal Microbiota Transplantation 21.3.6 Live Biotherapeutic Products 21.3.7 Antimicrobial Resistance 21.4 Which Regulatory Pathway Is Best? 21.5 Safety Considerations 21.5.1 Potential for Transmission of Infectious Agents 21.5.2 Long-Term Effects on the Host Microbiome 21.6 The Regulatory Framework for Preclinical Safety Assessment of Microbiome-Based Therapeutics 21.6.1 Toxicological Studies 21.6.2 Risk Mitigation Strategies 21.6.3 Monitoring Adverse Events 21.7 Efficacy and Clinical Development 21.8 Quality Control and Manufacturing 21.8.1 Ex Vivo Microbiome Assay 21.8.2 In Vitro Microbiome Assay 21.8.3 Immune Microbiome Interaction Profiling Assays 21.9 Manufacturing Process 21.9.1 Upstream Bioprocessing 21.9.2 Downstream Processing 21.9.3 Formulation 21.9.4 Reproducibility 21.9.5 Stability 21.9.6 Standardized Protocols 21.10 Post Market Surveillance and Pharmacovigilance 21.10.1 Commercialization Challenges 21.10.2 Monitoring Long-Term Safety and Effectiveness 21.11 Role of Pharmacovigilance 21.12 Future Prospective 21.13 Conclusion References 22: Microbiota-Based Therapeutics for COVID-19 and Sequelae 22.1 Introduction 22.2 Acute COVID-19 and Sequelae 22.3 The Gut–Lung Axis 22.4 Microbiota-Based Therapeutics 22.5 Clinical Studies Involving Microbiota Modulation 22.6 Conclusion References

This is the first book completely dedicated to positioning and navigation using machine learning methods. It deals with ground, aerial, and space positioning and navigation for pedestrians, vehicles, UAVs, and LEO satellites. Most of the major machine learning methods are utilized, including supervised learning, unsupervised learning, deep learning, and reinforcement learning. The book presents both fundamentals and in-depth studies as well as practical examples in positioning and navigation. Extensive data processing and experimental results are provided in the major chapters through conducting experimental campaigns or using in-situ measurements.

Humour in Old English Literature deploys modern theories of humour to explore the style and content of surviving writing from early medieval England. The book analyses Old English riddles, wisdom literature, runic writing, the deployment of rhymes, and humour in heroic poetry, hagiography, and romance.Drawing on a fine-tuned understanding of literary technique, the book presents a revisionist view of Old English literature, partly by reclaiming often-neglected texts and partly by uncovering ironies and embarrassments within well-established works, including Beowulf. Most surprisingly, Jonathan Wilcox engages the large body of didactic literature, pinpointing humour in two anonymous homilies along with extensive use in saints’ lives. Each chapter ends by revealing a different audience that would have shared in the laughter.Wilcox suggests that the humour of Old English literature has been scantily covered in past scholarship because modern readers expect a dour and serious corpus. Humour in Old English Literature aims to break that cycle by highlighting works and moments that are as entertaining now as they were then.This book explores the technique and significance of humour in Old English literature, including riddles, rhymes, the heroic, the hagiographic, and more.

This book summarizes various scalable and cost-effective techniques to fabricate different 2D materials beyond graphene including, but not limited to, transition metal dichalcognides (TMDs), MXenes, Transition Metal Oxides (TMOs), etc. This book focuses on recent advancements in the field of sensors based on these 2D materials and their heterostructures. These materials exhibit a wide range of sensing applications and have become one of the potential research areas for the scientific community due to their exceptional and tunable properties. This book provides basic and fundamental knowledge about various sensing mechanisms, challenges, and future opportunities for the fabrication/development of the next-generation sensors with applications in daily lives.

CONTENTS ABSTRACT “-WILL IT PERSIST?” POPULÄRVETENSKAPLIG SAMMANFATTNING LIST OF STUDIES ABBREVIATIONS INTRODUCTION HYPOTHESIS AIMS MATERIAL AND METHODS RESULTS DISCUSSION CONCLUSIONS FUTURE PERSPECTIVES ACKNOWLEDGEMENTS REFERENCES APPENDIX Studies

Geace and Horace Clifford lived in I ndiana, and so were called Hoosiers. Their home, with its charming grounds, was a little way out of town, and from the front windows of the house you could look out on the broad COO hio, a river which would be very beau-- .tiful, if its yellow waters were only once settled. (Typographical errors above are due to OCR software and don't occur in the book.) About the Publisher Forgotten Books is a publisher of historical writings, such as: Philosophy, Classics, Science, Religion, History, Folklore and Mythology. Forgotten Books' Classic Reprint Series utilizes the latest technology to regenerate facsimiles of historically important writings. Careful attention has been made to accurately preserve the original format of each page whilst digitally enhancing the aged text. Read books online for free at www.forgottenbooks.org

No Possessions, No Memories, Not Even A Name! The wounded stranger found on Jessica O'Malley's property has no idea who he is. And Jessica would be foolish to trust him after being proven so wrong about a former suitor who turned out to be a criminal. But Jessica's wariness toward the newcomer is soon turning to interest...and hope. Until he knows his true identity, "Grant" can't make a life in this quaint Tennessee town. He certainly shouldn't be thinking so much about the feisty redhead with beautiful, guarded eyes. But even as he fights to keep a distance from Jessica, his feelings for her grow. And he can't help but wonder if he'll want to return to his old life when his past is revealed. Smoky Mountain Matches: Dreams of home and family come true in the Smoky Mountains

This book provides a comprehensive view for plant microbe interactions towards stress management and microbiome-assisted approaches in sustainable agriculture. It is divided into four major sections. The book gives insights into the increasing threat of abiotic and biotic stresses and the accompanying challenges to modern agriculture. Through different chapters, the book shows how various microorganisms could ameliorate abiotic and biotic stress, and contribute towards food sustainability and restore ecosystem functioning. It provides a deep understanding of soil microbiome and its interaction with plants, to enhance food security. It further talks about metagenomic approaches for methodological tool for studying the soil microbiome. Separate sections on stress, talk at length about the various abiotic and biotic stresses that plants are faced it. The book culminates with an exciting section on microbiome-assisted approaches for combating stress. It talks about the different microbiomes such as rhizosphere, soil, phyllosphere and endophytic microbiome. The book would be beneficial to students, researchers and course instructors in microbiology, botany, plant pathology and agriculture.

A chilling tale about revisiting the past—and digging up secrets you’d rather forget.The invitation to her school reunion couldn’t have come at a better time for Chloe Flynn. Divorced, broke and bored at work, she’s living a life her teenage self would hate. Turning the clock back fifteen years might be just what she needs to wipe the slate clean and start again. And then there’s the chance she’ll bump into Nathan Blake, the one she still regrets letting get away...Back at her elite private school, Chloe sparkles as she reunites with old friends and long-forgotten love interests. And then, just as she’d hoped, there’s Nathan, more handsome than ever before. Even better, he’s single too, and seems to be just as keen to make up for lost time...But as the evening progresses, Chloe can’t help feeling that something’s not quite right—that she’s not the only one who’s come here for more than just a party. When the secrets of the past start to emerge and the reunion takes a sinister turn, it’s clear that nothing is what it seems—and nothing will be the same again.About the AuthorShalini Boland is the Amazon and USA Today bestselling author of eighteen psychological thrillers. To date, she’s sold over two million copies of her books.Shalini lives by the sea in Dorset, England, with her husband, two children and their increasingly demanding dog, Queen Jess. Before kids, she was signed to Universal Music Publishing as a singer/songwriter, but now she spends her days writing (in between restocking the fridge and dealing with endless baskets of laundry).She is also the author of two bestselling sci-fi and fantasy series as well as a WWII evacuee adventure with a time-travel twist.When she’s not reading, writing or stomping along the beach, you can reach her via Facebook at www.facebook.com/ShaliniBolandAuthor, on Twitter @ShaliniBoland, on Instagram @shaboland, on TikTok @shaliniboland or via her website: www.shaliniboland.co.uk.

Edited by his children, Giles and Victoria, Chocolate and Cuckoo Clocks is an anthology of writing from the former editor of Punch and Radio 4 national treasure Alan Coren, who died in October 2007.In a prolific forty-year career Alan Coren wrote for The Times, Observer, Tatler, Daily Mail, Mail on Sunday, Listener, Punch and the New Yorker, and published over 20 books including The Sanity Inspector, Golfing for Cats and The Collected Bulletins of Idi Amin. Even twenty years ago he estimated that he had published six million words, or ten copies of War and Peace.This anthology draws together the best of his published work as new unpublished autobiographical material.Coren was one of Britain's most prolific and now much-missed humourists, finding the comedy of life all around him and rendering it, hilariously and compellingly, in polished and witty prose...

The book is intended as a guide to tax disputes covering litigation on tax liability, collateral challenges to assessments, objections and reviews and appeals of objection decisions, advocacy and submissions, access to information, and expert evidence

당신은 ‘왜’ 보수입니까?당신은 ‘왜’ 진보입니까?설명하기 어렵다면 이 책을 읽어야 합니다최강욱 전 의원과 그의 동생 최강혁이 함께 쓴보수·진보의 역사와 정의, 현재의 쟁점과 시대적 과제까지남녀 노소 좌우를 모두 아우르는 민주 시민의 필독서위헌적 계엄과 탄핵, 대통령 파면을 넘어 조기 대선 정국에 들어선 대한민국은 다시 보수와 진보, 우파와 좌파 간의 치열한 전장이 되었다. 정치와 개혁의 최전선에서 활약하다 지금은 잠시 디지털 크리에이터(유튜버)로서 대중과 만나고 있는 최강욱 전 의원. 다양한 매체에서 촌철살인의 정치 평론을 선보이는 그에게 정치학을 전공한 동생 최강혁은 자주 당부했다. “건강한 보수의 성장을 위해서, 누군가는 보수의 가치와 장점을 계속 말해야 한다”고. 지금 우리 사회에는 그 어느 때보다 상대 진영을 향한 증오의 언어가 난무하고 있다. 적대적 공생관계를 이어 가는 극단적 대결 구도도 점점 심화되고 있다. ‘최강 형제’는 우리 정치가 갈라치기와 혐오에서 벗어나 화합과 연대로 나아가기 위해서는 보수와 진보가 서로에 대해 잘 알아야만 한다고 여겼고, 이를 도와줄 수 있는 쉽고 친절한 정치 교양서를 함께 써 보기로 했다. 신간 《이로운 보수 의로운 진보》는 생생한 정치 현장을 온몸으로 겪어 온 정치인이자 법률가인 형 최강욱, 정치에 대한 깊은 관심과 이론적 역량으로 무장한 동생 최강혁이 의기투합하여 만들어 낸 결과물이다.이 책에는 보수 성향의 ‘봉수 씨’와 진보 성향의 ‘진봉 씨’라는 50대 동갑내기 가상 인물이 등장한다. 이들의 대비되는 삶의 모습과 가치관은 보수와 진보의 세계관, 정치적 입장 차이를 극명하게 드러내 준다. 총 4부로 구성된 이 책의 1부 ‘보수와 진보의 위대한 탄생’에서는 ‘보수·진보’ ‘우파·좌파’ 개념이 어떻게 생겨났고 발전해 왔는지를 세계사적 배경, 프랑스혁명의 전개 과정 속에서 살펴본다. 2부 ‘보수와 진보는 어떻게 세상을 바라볼까’에서는 ‘봉수 씨’와 ‘진봉 씨’가 각 주제를 놓고 치열한 논쟁을 벌이고, 〈다크 나이트〉 〈킹스맨〉 〈기생충〉 〈죽은 시인의 사회〉 〈머니볼〉 〈설국열차〉 〈두 교황〉 등 익숙한 대중문화 콘텐츠를 통해 보수와 진보의 특징과 차이를 보여 준다. 지극히 일상 친화적이고 친절한 스토리텔링이어서 누구나 쉽게 내용의 흐름에 올라탈 수 있다. 3부 ‘혐오와 배척이 아닌 화합과 연대를 위해’에서는 가난과 빈부 격차, 평등과 복지, 능력주의와 학벌, LGBTQ, 낙태와 사형, 태극기부대와 키세스 시위대, 빈곤층의 보수성 등 우리 사회를 뜨겁게 달구는 이슈들에 대한 보수와 진보의 입장 차이, 각자가 추구하는 가치가 무엇이고 세상을 대하는 마음과 태도는 서로 어떻게 다른지를 알아본다. 마지막으로 4부 ‘이상적인 정치의 모델’에서는 이로운 보수의 모델로 독일의 앙겔라 메르켈 총리를, 의로운 진보의 모델로 미국의 버락 오바마 대통령을 소개하며, 우리나라에서 보수와 진보의 개념이 달라진 이유와 함께 진짜 보수정당과 새로운 진보정당 탄생에 대한 저자들의 기대를 이야기한다.바람직한 정치와 민주주의에 대한 관심이 다시 커지고 있다. 각자의 가치관과 정치적 성향 차이가 어디서 비롯된 것인지 모른 채 ‘무지성’으로 보수·진보를 지지하거나 배척하는 경우가 많다. 정치적 양극화가 심한 한국 사회에서는 특히, 자신과 다른 이념적 위치에 있는 이들을 적극적으로 이해하려고 노력할 때 비로소 진정한 사회 통합과 민주주의의 성숙이 가능해질 것이다. 그런 맥락에서 이 책은 특히 청소년과 청년처럼 아직 정치적 가치관이 정립되지 않은 세대에게 보다 균형 잡힌 지식과 시각을 선사한다. 중장년 독자에게는 오래도록 관철해 온 자신의 정치적 입장을 새삼 성찰해 볼 기회, 남들에게 내가 왜 보수(또는 진보)인지 자신 있게 설명할 수 있는 넉넉한 근거를 제공한다.

Hello! My name is Claude Davis and this is my 432 pages, color, hardcover (8.78 x 5.9 x 1 inches) . The SHTF we all prep for is what folks 150 years ago called daily life: no electrical power, no refrigerators, no Internet, no computers, no TV, no hyperactive law enforcement, and no Safeway or Walmart... The Lost Ways prepares you to deal with worst-case scenarios with the minimum amount of resources just like our forefathers lived their lives, totally independent from electricity, cars, or modern technology whatsoever, meaning you'll also be bulletproof against the ever-increasing threat of an Electro Magnetic Pulse, a Powerful Economic Breakdown, Famines, and Natural Disasters... **Please note that some of the pictures in the book are meant to look "old"...

This book constitutes refereed proceedings of the 3rd International Semantic Intelligence Conference (ISIC 2023). This book covers a wide range of topics, including semantic web engineering, ontology-based data access, multimodal and multilingual access, machine-to-machine communications and interoperability, knowledge extraction and ontology learning from the web, computational paradigms and computational intelligence, distributed and mobile systems, and many others. This book includes novel contributions and the latest developments from researchers across industry and academia. This book serves as a valuable reference resource for academics and researchers across the globe

This is the first book completely dedicated to positioning and navigation using machine learning methods. It deals with ground, aerial, and space positioning and navigation for pedestrians, vehicles, UAVs, and LEO satellites. Most of the major machine learning methods are utilized, including supervised learning, unsupervised learning, deep learning, and reinforcement learning. The book presents both fundamentals and in-depth studies as well as practical examples in positioning and navigation. Extensive data processing and experimental results are provided in the major chapters through conducting experimental campaigns or using in-situ measurements

The Chinese economy is currently undergoing fundamental changes. In this context, the 2022 China Update examines the key characteristics of China’s transition towards a new phase of economic growth and development. This year’s update book covers a range of diverse topics that reflect the complex and changing nature of the economy. It explores critical questions: Why does China need a new development paradigm, and what is the best way to achieve it? What are China’s choices when faced with the restructuring of global industrial value chains? What key roles will domestic consumption play in the next phase of China’s development? What does the digital transformation mean for the Chinese economy? What has been the domestic impact of the Covid-19 pandemic on income inequality and labour market outcomes? What pathways exist for China in its transition towards carbon neutrality? How does China’s emissions-trading market compare with that of Europe? How will China’s carbon neutrality strategy affect the Australian economy? What are the political factors influencing bilateral trade flows between China and its trading partners? And what is at stake for China–US relations?

This book provides a holistic approach of integrated mine planning and scheduling to optimize mining projects using the discounted cash flow rate of return (DCF-ROR) method. There are nine chapters in the book. Chapter 1 is the Introduction, which provides overviews of mineral assets, minerals in Australia, mineral exploration, mining methods, and significance of valuation, optimization, and integrated mine planning. Chapter 2 is the Mineral Resources and Ore Reserves Estimation, including grade composition method, inverse distance weighting method, ordinary Kriging method and block model. Chapter 3 is the Feasibility Study that delves into three phased feasibility study, namely scoping, prefeasibility and feasibility studies, data requirements, risk identification and mitigation in the feasibility study, and mining project cost estimation. Chapter 4 is the Valuation of Mineral Projects. It starts with the time value of money; followed by methods to calculate cash flow, discounted cash flow (DCF), net present value (NPV), internal rate of return (IRR) and payback period; valuation methods, including market-, income-, and cost-based approaches; and finally the sensitivity study of key factors influencing the valuation of mining projects. Chapter 5 is the Mine Planning and Open Pit Optimization that covers different types of mine planning, block model valuation, Lerchs-Grossmann and floating cone techniques for pit optimization. Chapter 6 is the Life of Mine Optimization that details a case study of strip mining optimization using the DCF-ROR method and integrated LOM optimization of open pit mining. Chapter 7 is the Production Schedule Optimization of Surface Mining, covering production schedule optimization, equipment availability and utilization, and loading and hauling equipment match optimization. Chapter 8 is the Optimization of Underground Mine Planning and Scheduling that delves to a case study of room and pillar mining optimization using the DCF-ROR method...

He is a king, a warrior, the last hope of his people–and the chosen one of the sidhe ...Rhiann knows that demons walk the night. She has been taught to fear them. But from the moment Cade is dragged before her father's throne, beaten and having lost all of his men to her father's treachery, he stirs something inside her that she has never felt before. When Cade is revealed to be not only Arthur's heir but touched by the sidhe, Rhiann must choose between the life she left behind and the one before her--and how much she is willing to risk to follow her heart.The Last Pendragon is the first book in The Last Pendragon Saga.The Complete Series reading order: The Last Pendragon, The Pendragon's Blade, Song of the Pendragon, The Pendragon's Quest, The Pendragon's Champions, Rise of the Pendragon, The Pendragon's Challenge, Legend of the Pendragon.

The Yoga Sutras of Patanjali, translated by Ranjit Chaudhri, provides invaluable insights into the age-old practice of yoga. Chaudhri's translation skillfully captures the essence of Patanjali's teachings, highlighting the journey toward liberation and enlightenment through the path of yoga. With its clarity and profound depth, this translation serves as an invaluable companion for practitioners aiming to deepen their comprehension of yoga philosophy and harness its transformative potential in achieving harmony of body, mind, and spirit.Escape the Noise of Everyday Life and Connect with Your True Self!• A comprehensive and authentic rendering of the ancient text, ensuring accuracy and reliability.• Allows practitioners to deepen their understanding of the philosophy and principles of yoga.• Offers insights and guidance that can be applied and incorporated into any stage of the yoga journey.• Offers wisdom that can be applied to various aspects of life, fostering personal growth, self-awareness, and spiritual development.• Helps individuals to explore the depths of this ancient practice and integrate it into their modern lives.Ranjit Chaudhri is a national best selling author who has translated some important texts of Yoga and Kashmir Shaivism from Sanskrit to English. These include, The Shiva Sutras: Eternal Wisdom for Life, 112 Meditations for Self Realization: The Vigyan Bhairava Tantra, Sounds of Liberation: The Spanda Karikas and The Yoga Sutras of Patanjali. He believes the wisdom of some of our ancient spiritual texts can lead to self-transformation and make the world a better place. His extensive knowledge of yoga, gained from over forty years of experience, helps to explain and clarify the profound messages of the texts he has translated. He attended Brandeis University and the London School of Economics. He presently lives in Kolkata.

Reinvent & Outperform: Becoming a Better Leader is a compelling and insightful guide on leadership, drawn from Eugene S Acevedo's extensive experience and thoughtful musings. From formal training at the Asian Institute of Management to practical mentoring at Citibank, the author has a rich background in developing effective leaders.The book covers leadership, strategy, career development, mentorship, and digital banking. It offers readers a chance to grow, reflect, and become better leaders.

Contemporary Moroccan Thought offers a new and broad coverage of the intellectual dynamics and scholarly output of what is presented here as the Rabat School since the 1950s. Geographically situated at the western edge of the classical Arab-Islamic world, Moroccan scholarship has made a belated yet vigorous comeback on the modern Arab intellectual scene, attracting wider reception beyond the Arabic-speaking world, through influential contributions in philosophical, theological, social and cultural studies. This volume sets a new standard in the study of Moroccan, North African, and Middle Eastern societies, and will undoubtedly remain an important scholarly reference for generations to come. Contributors Deina Abdelkader, Nayla Abi Nader, Kholoud Al-Ajarma, Salah Basalamah, Mohamed Wajdi Ben Hammed, Sara Borrillo, Ibrahim Bouhaouliane, Tina Dransfeldt Christensen, Driss El Ghazouani, Brahim El Guabli, Abdennabi El Harri, Amin El-Yousfi, Francesca Forte, Fatma Gargouri, Wael Hallaq, Mohammed Hashas, Alma Rachel Heckman, Aziz Hlaoua, Abdellatif Kidai, Markus Kneer, Mohamed Lamallam, Khalid Lyamlahy, Juan A. Macías-Amoretti, Djelloul Magoura, Mohammed K. B. Rhazzali, Raja Rhouni, Nils Riecken, Fatima Sadiqi, Hamza Salih, Ari Schriber, Simone Sibilio, and Abdessalam Tawil.

It’s a normal afternoon when I walk out the patio doors of our kitchen to check on Mia, my stepdaughter, who is swimming in our backyard pool. But she’s gone. My heart stops when I see the back gate is open, her pink, fluffy towel lying folded on a chair. I was just feet away. Why didn’t I hear her scream? Who took our little girl? My husband can’t understand how I could have let his daughter disappear. And when the police come asking questions, I wish I could wind back time to that normal afternoon when I was cooking lasagna for my family, Mia’s favorite. I can tell the officers don’t believe me: they’ve cast me as the evil stepmother. I just wish I could understand the messages I’ve found from my husband on Mia’s phone: I’m so sorry, I still love you. And why his wedding ring is found at the bottom of the pool after Mia disappeared. He never told me it was missing. What else is he hiding? But the detective keeps asking me where I was during those ten minutes when Mia vanished. And I can’t tell her my secret. From the way she’s looking at me, I know she thinks I did something to my stepdaughter. Mia and I haven’t always been that close and sometimes she drives me nuts, just like any normal teenager, but I would never hurt her. I just need you to believe me. A twisty novel packed with unputdownable suspense about the power and damage of secrets we hide. Perfect for anyone who was totally hooked by The Mother-in-Law, Kerry Fisher and Big Little Lies. Readers are utterly gripped by The Stepdaughter! “Wow!! Where do I begin? What an absolutely gripping, intense psychological thriller that will keep you on the edge of your seat, flying through the pages and full of suspense!!... I cannot wait to read more books by the very talented Georgina Cross who I will definitely be adding to my top authors list!!! A mind-blowing, suspense-filled, psychological, page-turning thriller!!!” Goodreads Reviewer ⭐️⭐️⭐️⭐️⭐️ “Wowser! This was a fast mover. I literally read The Stepdaughter in two sittings and don’t know where today went... I think I suspected just about everyone at some point... I’d definitely recommend this book to fast-paced psychological thriller lovers. It’s not one to be missed. Be prepared to lose time once you start reading!” NetGalley Reviewer ⭐️⭐️⭐️⭐️⭐️ “Awesome book! I Absolutely LOVED this book!! I liked the characters and the story was so good, the ending got me. All in all, a Great read.” NetGalley Reviewer ⭐️⭐️⭐️⭐️⭐️ “Oh my word what a brilliant book this is, it got me interested from the very first page... and soon became a fast-paced psychological thriller which I couldn’t put down. It was extremely well written, excellent characters, brilliantly addictive. I was...

This book is published in English that fully reveals why the Bank of Japan (BOJ) under Governor Haruhiko Kuroda has failed to end deflation. The BOJ’s monetary policy was based on the theories of reflationist economists such as Kikuo Iwata. They argued that if the BOJ adopted an inflation target that had a deadline for meeting that goal, clarified the Bank’s responsibility, and supplied a large monetary base through a quantitative easing policy, inflation expectations would rise and deflation would be overcome.This book shows that there is no theoretical basis or evidence for this claim. Furthermore, the supply of a large monetary base itself became impossible and was abandoned in 2016. However, since publicly stating that overcoming deflation is impossible would incur embarrassment and a loss of confidence, the BOJ made it appear as if a former policy was still in place.

This book presents a concept of the role of police in society as basically repressive. The authors give a historical account of the rise of police from early slave patrols to the present to bolster their position that the police are a repressive force. Instances of police brutality and police control of demonstrators are examined. Technological advances and equipment to aid police departments are pointed to as examples in the police arsenal of repression. Police political surveillance is described, and private security police come under fire also for protecting corporate property and investments.

To elucidate the theoretical underpinnings and practical nuances of China's Outward Foreign Direct Investment (OFDI) in Indonesia spanning 1990-2022, this book intricately integrates its evolutionary trajectory within the framework of both traditional and emerging investment theories. Employing a judicious blend of standardized and empirical approaches, the book employs a comprehensive mix of quantitative and qualitative research methods to provide a nuanced understanding of this dynamic subject matter. Against the backdrop of the post-pandemic era, this book takes the international investment landscape as its context, focusing on Indonesia as the subject of country-specific research. It demonstrates the evolutionary trajectory of China's enterprises' direct investment in Indonesia, synthesizing the structural characteristics of these investments. The study empirically examines the investment effects and their operational mechanisms, determining the multi-dimensional investment distances between the two countries. Additionally, it illustrates the mechanisms underpinning the occurrence of the "liability of foreignness" risks faced by Chinese enterprises and defines the core elements and implementation pathways of the innovative localization investment model.

"What I then saw and heard of contemporary America so fascinated me that—believing as I do that the key to every people is in its past—I could not rest until I had mastered all that I could of the history of my delightful hosts. This I sought as much as possible from the original sources, reading voraciously, and at the time merely for my pleasure, such records as I could get of old debates and of the speech and correspondence of the dead." "History of the United States" by Cecil Chesterton is an easy-to-read synopsis of US history from the perspective of a British scholar. This is History at it's best.

Imaging in Reconstructive Microsurgery represents the first book in its kind the the Plastic Surgery and Reconstructive Microsurgery Community. This books includes all the imaging modalities available for plastic and reconstructive surgeons which adds major steps in the daily clinical practice. Most of these imaging modalities can and should be used by the operating surgeon her/himself to exponentially enhance and empower the clinical practice. This book provides step-by-step description of all the state-of-art imaging modalities for both perforator flap and lymphatic surgery, with the aim to provide a daily reference to colleagues who are novel to these procedures and for those who are looking forward to improve their practice. Encorporating imaging technology in clinical practice represents a paradigm shift in daily clinical practice with major enhancement of safety, minimal invasiveness and creativity finally leading to a next generation reconstructive approach. We believe that those imaging modalities will guide us to the future of microsurgery and super- microsurgery. This book will be the beginning of reader’s new journey.

Critical posthumanism is a theory paradigm that has become hugely influential across the humanities and social sciences in the last twenty years. This volume collects essays written over the last decade by one of the founders and leading figures of this movement. Originally a reaction to accelerated technological and media change that challenges traditional notions of what it means to be human, posthumanism (as opposed to transhumanism) has developed into a general critique and reappraisal of life after humanism and anthropocentrism. The essays collected here are dealing with aspects of education, technology, politics, media and art, and share a focus on how to critique and unlearn traditional understandings of humanness and (re)learn what it means to be human differently.

Lie back and think of England... England, 1904. Two years ago, Captain Archie Curtis lost his friends, fingers, and future to a terrible military accident. Alone, purposeless and angry, Curtis is determined to discover if he and his comrades were the victims of fate, or of sabotage. Curtis’s search takes him to an isolated, ultra-modern country house, where he meets and instantly clashes with fellow guest Daniel da Silva. Effete, decadent, foreign, and all-too-obviously queer, the sophisticated poet is everything the straightforward British officer fears and distrusts. As events unfold, Curtis realizes that Daniel has his own secret intentions. And there’s something else they share—a mounting sexual tension that leaves Curtis reeling. As the house party’s elegant facade cracks to reveal treachery, blackmail and murder, Curtis finds himself needing clever, dark-eyed Daniel as he has never needed a man before...