About Vintage Paperback Pulp Fiction: A new revolution was underway at the start of the 1940s in America—a paperback revolution that would change the way publishers would produce and distribute books and the reading public would consume them. In 1939 a new publishing company—Pocket Books—stormed onto the scene with the publication of its first paperbound book. Unlike hardback books, these pulp paperbacks were available in drugstores, newsstands, bus and train stations, and cigar shops. The American public could not get enough of them. The popular pulp genres reflected the tastes of Americans during the 1930s and 1940s—mysteries, thrillers, and "hardboiled detective" stories were all the rage. In the early 1950s new pulp fiction sub-genres emerged—science fiction, lesbian fiction, juvenile delinquent and sleaze, for instance—that would tantalize readers with gritty, realistic and lurid stories never seen before. Publishers had come to realize that sex sells. In a competitive frenzy for readers, they turned to alluring covers that often featured a sexy woman in some form of undress, along with a suggestive tag line that promised sex and violence within. To this day, the pulp cover art of these vintage paperback books are just as sought after as the books themselves were sixty years ago. We are excited to make these wonderful pulp fiction stories available in ebook format to new generations of readers, as a new revolution—the ebook revolution—is in full swing. We hope you will enjoy this nostalgic look back at a period in American history when dames were dangerous, tough-guys were deadly and dolls were downright delicious.

Like a dark jewel, there are many facets to a curse, as The Bellringer now learns... The conspiracy has formed. Robby will make his bid to become King. First he must go to the mythical place called Griferis, on the far side of the world. But no sooner than their journey begins, Robby and his band of friends face delay and obstacle. Along the way, they make new acquaintances, people both inscrutable and mysterious. Lord Tallin, brooding and powerful, haunted and paralyzed by a perfect memory. But he is the only person who can buy Robby the time he needs, if only he can shake himself to action. Lyrium, an Elifaen Firstborn, mysterious and secretive, come to test Robby, and to advise him. But when she meets Robby's companions, one in particular, she is filled with wonder, and with foreboding. Esildre, beautiful and enigmatic, fighting against the curse that Secundur put upon her. One of Robby's companions will soon fall prey to her enchantment. When Robby and his companions are captured by pixies, he bargains for their freedom, and risks unleashing the little folk upon an unsuspecting world. Meanwhile, he is trailed by mercenaries, tracked by black eagles, and followed by an elusive Dreamwalker who holds the key to Robby's greatest power. And darker forces now stir, forces that only Robby can thwart. But only if he can reach Griferis in time. ——————————————————————————————————————————————— About The Year of the Red Door: 244 Days Remain. That is all. The Year of the Red Door has begun, and four months have already passed by. This is the story of the last 244 days. Uncanny things are taking place in the world, mysterious powers are stirring, and there are signs of coming change. Like pieces on a game-board, ancient forces are moving into position, gathering strength. Many sense the portents and see the signs, but few know their meaning. Fewer still understand what must be done. But who is there to do it? In only 244 days, six intrepid travelers must cross thousands of miles, to the far edge of the world, to find a place that may not even exist. A legendary place called Griferis where a new king may be prepared, trained, and judged for worthiness. It is their bid to find that place, to discover the secret Name of the King, and to make one of their companions the new King. But hope is thin, and time runs out. Can the Name be found? Can the Usurper use it to take the throne? And will it make any difference? It already seems too late. In the spirit of J.R.R. Tolkien and Charles Dickens comes a new heroic tale, a story of ageless love and brave determination, of tragic loss and the hope of redemption. During this quest, mythic powers arise from the ancient past, fate collides with destiny, and the world edges swiftly to its final destruction or to its ultimate fulfillment. Only the Bellringer can tip the balance of fate, but the world is almost out of time...

For centuries, the Great Bell was silent... It remained undisturbed, nearly forgotten by history, hidden away in the ruins of an abandoned fortress. The enchantments within its iron slumbered, its secrets protected by silence. Until someone discovered how to ring the Bell, other secrets would remain safe. One day, while running an errand, a young store clerk took a wrong turn, then another, until he found himself deep within the old fortress where the Great Bell waited. It waited for him. And when the hapless clerk rang the Great Bell and released its enchantments, his troubles began. For he had become the Bellringer. He claimed it was all an accident, that he did not mean to ring the Bell. Fate, it seemed, thought otherwise, and proof of the Bellringer's destiny began to emerge just as the world spiraled into war. Revolt and treachery worked to break apart the Seven Realms. Armies were on the march. The faraway King, obsessed with his own power, seemed unwilling or unable to prevent the looming catastrophe. Perhaps a new King was needed...if only someone could penetrate the secret of the King's power and take the throne before it was too late. It was foretold that the person who discovered the True Name of the King would become the next King. But who was capable of such a thing? The Bellringer. About The Year of the Red Door 244 Days Remain. That is all. The Year of the Red Door has begun, and four months have already passed by. This is the story of the last 244 days. Uncanny things are taking place in the world, mysterious powers are stirring, and there are signs of coming change. Like pieces on a game-board, ancient forces are moving into position, gathering strength. Many sense the portents and see the signs, but few know their meaning. Fewer still understand what must be done. But who is there to do it? In only 244 days, six intrepid travelers must cross thousands of miles, to the far edge of the world, to find a place that may not even exist. A legendary place called Griferis where a new king may be prepared, trained, and judged for worthiness. It is their bid to find that place, to discover the secret Name of the King, and to make one of their companions the new King. But hope is thin, and time runs out. Can the Name be found? Can the Usurper use it to take the throne? And will it make any difference? It already seems too late. In the spirit of J.R.R. Tolkien and Charles Dickens comes a new heroic tale, a story of ageless love and brave determination, of tragic loss and the hope of redemption. During this quest, mythic powers arise from the ancient past, fate collides with destiny, and the world edges swiftly to its final destruction or to its ultimate fulfillment. Only the Bellringer can tip the balance of fate, but the world is almost out of time... ==> Content Aspects of The Bellringer

Cover 1 Half-title 3 Title 5 Copyright 6 Dedication 7 Contents 9 Illustrations 14 Preface 15 Acknowledgements 16 Introduction: The challenge 17 The literary and cultural criticism 19 A crisis of the ‘natural’ 21 A reading 24 Romantic and anti-romantic 29 Romantic and ‘romantic’ 29 Chapter 1 Old world romanticism 31 Romantic ecology 31 The self-evidence of the natural? 34 The inherent greenness of the literary? 35 A reading: the case of John Clare 37 Chapter 2 New world romanticism 41 A reading: retrieving Walden 46 Chapter 3 Genre and the question of non-fiction 51 ‘You don’t make it up’ 52 Fiction or non-fiction? 54 An aesthetic consumerism 55 A reading: genres and the projection of animal subjectivity 58 Chapter 4 Language beyond the human? 62 A realist poetics 63 The Spell of the Sensuous (1996) 64 Chapter 5 The inherent violence of western thought? 71 The archetypal eco-fascist? 75 The forest 76 Chapter 6 Post-humanism and the ‘end of nature’? 79 A reading: Frankenstein 82 Ecology without nature? 85 The boundaries of the political 89 Chapter 7 Thinking like a mountain? 93 Chapter 8 Environmental justice and the move ‘beyond nature writing’ 103 A reading: A River Runs Through It (1976) 106 Environmental criticism as cultural history? 109 Chapter 9 Two readings: European ecojustice 112 Chapter 10 Liberalism and green moralism 118 The limits of liberal criticism 121 A reading: William and Dorothy Wordsworth 124 Chapter 11 Ecofeminism 127 An ecriture ecofemine? 130 ‘Nature provides us with few givens’ (Lealle Ruhl) 133 Chapter 12 ‘Post-colonial’ ecojustice 136 Environmentalism as neocolonialism? 136 Is there yet a specifically environmental post-colonial criticism? 138 A reading: Amitav Ghosh, The Hungry Tide (2004) 142 Chapter 13 Questions of scale: The local, the national and the global 146 Literary ‘reinhabitation’? 148 Questions of scale 152 Science and the struggle for intellectual authority 157 Chapter 14 Science and the crisis of authority 159 The disenchantment thesis 159 Facts versus values? a reading, Annie Dillard’s ‘Galapagos’ 161 Against the facts–values split 164 Ecology, ‘ecology’ and literature 167 Chapter 15 Science studies 172 Studying science as a kind of behaviour 172 Donna Haraway 174 Chapter 16 Evolutionary theories of literature 181 The Standard Social Science Model 181 Literature and human nature 183 Chapter 17 Interdisciplinarity and science: Two essays on human evolution 187 The animal mirror 195 Chapter 18 Ethics and the non-human animal 199 Human–animal 202 Chapter 19 Anthropomorphism 208 An art of animal interpretation 211 A reading: The Wind in the Pylons 214 Chapter 20 The future of ecocriticism 218 Notes 220 Introduction 220 Romantic and anti-romantic 221 1 Old world romanticism 221 2 New world romanticism 222 3 Genre and the question of non-fiction 224 4 Language beyond the human? 225 5 The inherent violence of western thought? 227 6 Post-humanism and the ‘end of nature’? 228 The boundaries of the political 229 7 Thinking like a mountain? 229 8 Environmental justice and the move ‘beyond nature writing’ 230 9 Two readings: European ecojustice 231 10 Liberalism and green moralism 232 11 Ecofeminism 233 12 ‘Post-colonial’ ecojustice 235 13 Questions of scale: the local, the national and the global 237 Science and the struggle for intellectual authority 239 14 Science and the crisis of authority 239 15 Science studies 241 16 Evolutionary theories of literature 242 17 Interdisciplinarity and science: two essays 243 The animal mirror 244 18 Ethics and the non-human animal 244 19 Anthropomorphism 245 20 The future of ecocriticism 246 Further reading 247 Introduction 247 General sources 247 Journals 247 General critical anthologies 247 Other useful overviews 248 Definitions of ‘nature’ 248 Climate change 248 Romantic and anti-romantic 249 1 Old world romanticism 249 ‘Deep ecology’ 249 2 New world romanticism 250 3 Genre and the question of non-fiction 251 4 Language beyond the human? 251 5 The inherent violence of western thought? 252 6 Post-humanism and the ‘end of nature’? 252 The boundaries of the political 253 7 Thinking like a mountain? 253 8 Environmental justice and the move ‘beyond nature writing’ 253 ‘Social ecology’ 254 9 Two readings: European ecojustice 254 10 Liberalism and green moralism 255 11 Ecofeminism 255 12 ‘Post-colonial’ ecojustice 256 Overpopulation 256 13 Questions of scale: the local, the national and the global 256 Science and the struggle for intellectual authority 257 14 Science and the crisis of authority 257 15 Science studies 257 16 Evolutionary theories of literature 258 17 Interdisciplinarity and science: two essays on human evolution 258 The animal mirror 258 18 Ethics and the non-human animal 258 19 ‘Anthropomorphism’ 259 Index 260

This book was converted from its physical edition to the digital format by acommunity of volunteers. You may find it for free on the web. Purchase of theKindle edition includes wireless delivery.Auszeichnung : isbn searchedwords : 29922

Poke Rafferty was writing offbeat travel guides for the young and terminally bored when Bangkok stole his heart. Now the American expat is assembling a new family with Rose, the former go-go dancer he wants to marry, and Miaow, the tiny, streetwise urchin he wants to adopt. But trouble in the guise of good intentions comes calling just when everything is beginning to work out. Poke agrees to take in Superman, Miaow's troubled and terrifying friend from the gutter. Then he agrees to help locate a distraught Aussie woman's missing uncle and accepts a generous payment to find a blackmailing thief. No longer gliding carelessly across the surface of a culture he doesn't really understand, suddenly Poke is plodding through dark and unfamiliar terrainand everything and everyone he loves is in terrible danger. From Publishers Weekly Brutal torture and equally brutal empathy define this excellent, if sometimes familiar, thriller from Hallinan ( The Bone Polisher ). Poke Rafferty, a travel writer turned detective, intends to settle down in Bangkok with his ex-prostitute girlfriend, Rose, and a young urchin, Miaow, when Miaow brings her troubled friend Superman into the household. While dealing with this intrusion, Rafferty takes on dual sleuthing assignments to help pay for adopting Miaow. The first case involves finding Australian Claus Ulrich, a hardcore bondage aficionado. When Rafferty meets the powerful and rich Madame Wing while investigating Ulrich's disappearance, she offers him $30,000 to find an envelope and the Cambodian man who took it. The only catch? If Rafferty opens the envelope, he'll learn information about Madame Wing that will force her to kill him. Rafferty stumbles through the clues like the foreigner he is, always on the outside looking in. Despite an overly leisurely ending, the rich depictions of Bangkok's seedy side recall John Burdett's visceral mysteries. (July) Copyright Reed Business Information, a division of Reed Elsevier Inc. All rights reserved. From Booklist The author of the 1990s Simeon Grist series returns with a compelling new protagonist: American travel writer Poke Rafferty, who is out to right some serious wrongs on the predatory streets of Bangkok. While attempting to adopt a homeless girl, rescue a potentially murderous urchin known as Superman, and build a lasting relationship with the former bar girl he loves, Poke is pulled into two brutal mysteries. One involves a notorious Khmer Rouge torturer, the other a series of child-porn photos. As he doggedly plumbs these ghastly depths, Rafferty matures from a play-it-as-it-lays layabout into a man willing to meet his lover's culture more than halfway and find his moral compass at a time when the victims can be as guilty as the murderers are innocent. The fact that the referenced pedophile photo series and Phnom Penh torture house both existed heightens the impact of a narrative that's already deeply felt. If this opens a new series, Hallinan is off to a surefooted start with a supporting cast (including Poke's precocious, pugnacious, almost-daughter Miaow) well worth getting to know. Sennett, Frank

The Trinity Manifesto -A Program for our TimeThe fundamental crisis of the twentieth century is neither political, nor social, nor economic. It is intellectual, and the primary intellectual problem is neither metaphysical nor ethical: It is epistemological. No attempt to solve the various problems and end the seemingly interminable crises of the twentieth century will be successful unless it is recognized that the justification of knowledge is always the ultimate problem, and that unless this problem is solved, no other problem can be.In past centuries the secular philosophers have generally believed that knowledge is possible to man. Consequently they expended a great deal of thought and effort trying to justify knowledge. In the twentieth century, however, the optimism of the secular philosophers has all but disappeared. They despair of knowledge. Like their secular counterparts, the great theologians and doctors of the church taught that knowledge is possible to man. Yet the theologians of the twentieth century have repudiated that belief. They also despair of knowledge. This radical skepticism has filtered down from the philosophers and theologians and penetrated our entire culture, from television to music to literature. The Christian in the twentieth century is confronted with an overwhelming cultural consensus-sometimes stated explicitly, but most often implicitly: Man does not and cannot know anything truly.What does this have to do with Christianity? Simply this: If man can know nothing truly, man can truly know nothing. We cannot know that the Bible is the Word of God, that Christ died for sin, or that Christ is alive today at the right hand of the Father. Unless knowledge is possible, Christianity is nonsensical, for it claims to be knowledge. What is at stake in the twentieth century is not simply a single doctrine, such as the Virgin Birth, or the existence of Hell, as important as those doctrines may be, but the whole of Christianity itself. If knowledge is not possible to man, it is worse than silly to argue points of doctrine-it is insane.The Age of IrrationalismHistorians have christened the thirteenth century the Age of Faith and termed the eighteenth century the Age of Reason. The twentieth century has been called many things: the Atomic Age, the Age of Inflation, the Age of Envy, the Age of Aquarius. But it deserves one name more than the others: the Age of Irrationalism. Contemporary secular intellectuals are anti-intellectual. Contemporary philosophers are anti-philosophy. Contemporary theologians are anti-theology. The irrationalism of the present age is so thoroughgoing and pervasive that even the Remnant-the segment of the professing church that remains faithful-has accepted much of it, frequently without even being aware of what it was accepting. In some circles this irrationalism has become synonymous with piety and humility, and those who oppose it are denounced as rationalists-as though to be logical were a sin. Our contemporary anti-theologians make a contradiction and call it a Mystery. The faithful ask for truth and are given absurdity. If any balk at swallowing the absurdities of the anti-theologians, they are frequently marked as heretics or schismatics who seek to act independently of God.There is no greater threat facing the true church of Christ at this moment than the irrationalism that now controls our entire culture. Communism, guilty of tens of millions of murders, including those of millions of Christians, is to be feared, but not nearly so much as the idea that we, as Christian men, do not and cannot know truth. Hedonism, the popular philosophy of America, is not to be feared so much as the belief that logic-that “mere human logic,” to use the religious irrationalists’ own phrase-is futile. The attacks on truth, on revelation, on the intellect, and on logic are renewed daily. But note well: The misologists-the haters of logic-use logic to demonstrate the futility of using logic. The anti-intellectuals construct intricate intellectual arguments to prove the insufficiency of the intellect. The anti-theologians use the revealed Word of God to show that there can be no revealed Word of God-or that if there could, it would remain impenetrable darkness and mystery to our finite minds.Nonsense Has ComeIs it any wonder that the world is grasping at straws-the straws of mysticism and drugs? After all, if people are told that the Bible contains insoluble mysteries, then is not a flight into mysticism to be expected? On what grounds can it be condemned? Certainly not on logical grounds or Biblical grounds, if logic is futile and the Bible mysterious. Moreover, if it cannot be condemned on logical or Biblical grounds, it cannot be condemned at all. If people are going to have a religion of the mysterious, they will not adopt Christianity: They will have a genuine mystery religion.”Those who call for Nonsense,” C.S. Lewis once wrote,”will find that it comes.” And that is precisely what has happened. The popularity of Eastern mysticism and of drugs is the logical consequences of the irrationalism of the twentieth century. There can and will be no Christian revival-and no reconstruction of society-unless and until the irrationalism of the age is totally repudiated by Christians.The Church DefenselessYet how shall they do it? With only a few exceptions-really only one exception-Christendom is being taught by the irrationalists. The seminaries, which annually train thousands of men to teach millions of Christians, are the finishing schools of irrationalism, completing the job begun by the public schools and colleges. Some of the pulpits of the most conservative churches (we are not speaking of the apostate churches) are occupied by graduates of the anti-theological schools. These products of modern anti-theological education, when asked to give a reason for the hope that is in them, can generally respond with only the intellectual analogue of a shrug-a mumble about mystery. They have not grasped-and therefore cannot teach those for whom they are responsible-the first truth: “And ye shall know the truth.” Many, in fact, explicitly deny it, saying that, at best, we possess only “pointers” to the truth, or something “similar” to the truth, a mere analogy. Is the impotence of the Christian church a puzzle? Is its legalistic antinomianism a riddle? Is the fascination with Pentecostalism and faith healing among members of conservative churches an enigma? Not when one understands the sort of studied nonsense that is purveyed in the name of God in the seminaries.The Trinity FoundationThe creators of The Trinity Foundation firmly believe that theology is too important to be left to the licensed theologians-the graduates of the schools of theology. They have created The Trinity Foundation for the express purpose of teaching the faithful all that the Scriptures contain-not warmed over, baptized, secular philosophies. Each member of the board of directors of The Trinity Foundation has signed this oath: “I believe that the Bible alone and the Bible in its entirety is the Word of God and, therefore, inerrant in the autographs. I believe that the system of truth presented in the Bible is best summarized in the Westminster Confession of Faith. So help me God.”The ministry of The Trinity Foundation will be the presentation of the system of doctrine taught in Scripture as clearly and unambiguously as possible. We do not regard obscurity as a virtue, nor confusion as a sign of spirituality. Confusion, like all error, is sin, and teaching that confusion is all that Christians can hope for is doubly sin.Proving All ThingsThe presentation of the truth of Scripture necessarily involves the rejection of error. The Foundation will expose the irrationalism of the twentieth century, whether its current spokesman be an existentialist philosopher or a professed Reformed theologian. We will oppose anti-intellectualism, whether it be espoused by a neo-orthodox theologian or a fundamentalist evangelist. We will reject misology, whether it be on the lips of a neo-evangelical or those of a Roman Catholic charismatic. To each error we will bring the brilliant light of Scripture, proving all things, and holding fast to that which is true.The Primacy of TheoryThe ministry of The Trinity Foundation is not a “practical” ministry. If you are a pastor, we will not enlighten you on how to organize an ecumenical prayer meeting in your community. If you are a housewife, you will have to read elsewhere to find out how to become a total woman. If you are a businessman, we will not tell you how to develop asocial conscience. The professing church is drowning in such “practical” advice.The Trinity Foundation is unapologetically theoretical in its outlook, believing that theory without practice is dead, and that practice without theory is blind. The trouble with the professing church is not primarily in its practice, but in its theory. Christians do not know, and many do not even care to know, the doctrines of Scripture. Doctrine is intellectual, and Christians are generally anti-intellectual. Doctrine is ivory tower philosophy, and they scorn ivory towers. The ivory tower, however, is the control tower of a civilization. It is a fundamental, theoretical mistake of the practical men to think that they can be merely practical, for practice is always the practice of some theory. The relationship between theory and practice is the relationship between cause and effect. If a person believes correct theory, his practice will tend to be correct. The practice of contemporary Christians is immoral because it is the practice of erroneous theory. It is a major theoretical mistake of the practical men to think that they can ignore the ivory towers of the philosophers and theologians as irrelevant to their lives. Every action that the practical men take is governed by the thinking that has occurred in some ivory tower-whether that tower be the British Museum, the Academy, a home in Basel, Switzerland, or a tent in Israel.In Understanding Be MenIt is the first duty of the Christian to understand correct theory-correct doctrine-and thereby implement correct practice. This order-first theory, then practice-is both logical and Biblical. It is, for example, exhibited in Paul’s epistle to the Romans, in which he spends the first eleven chapters expounding theory and the last five discussing practice. The contemporary teachers of Christians have not only reversed the order, they have inverted the Pauline emphasis on theory and practice. The virtually complete failure of the teachers of the professing church to instruct the faithful in correct doctrine is the cause of the misconduct and cultural impotence of Christians. Twentieth-century American Christians are children carried about with every wind of doctrine, not knowing what they believe, or even if they believe anything for certain.The chief purpose of The Trinity Foundation is to counteract the irrationalism of the age and to expose the errors of the teachers of the church. Our emphasis-on the Bible as the sole source of truth, on the primacy of the intellect, on the supreme importance of correct doctrine, and on the necessity for systematic and logical thinking-is almost unique in Christendom. To the extent that the church survives-and she will survive and flourish-it will be because of her increasing acceptance of these basic ideas and their logical implications. We believe that The Trinity Foundation is filling a vacuum in Christendom. We are saying that Christianity is intellectually defensible-that,in fact, it is the only intellectually defensible system of thought. We are saying that God has made the wisdom of this world-whether that wisdom be called science, religion, philosophy, or common sense-foolishness. We are appealing to all Christians who have not conceded defeat in the intellectual battle with the world to join us in our efforts to raise a standard to which all men of sound mind can repair.The love of truth, of God’s Word, has all but disappeared in our time. We are committed to and pray for a great instauration. But though we may not see this reformation of Christendom in our lifetimes, we believe it is our duty to present the whole counsel of God because Christ has commanded it. The results of our teaching are in God’s hands, not ours. Whatever those results, his Word is never taught in vain, but always accomplishes the result that he intended it to accomplish. Gordon H. Clark has stated our view well:There have been times in the history of God’s people, for example, in the days of Jeremiah, when refreshing grace and widespread revival were not to be expected: The time was one of chastisement. If this twentieth century is of a similar nature, individual Christians here and there can find comfort and strength in a study of God’s Word. But if God has decreed happier days for us and if we may expect a world-shaking and genuine spiritual awakening, then it is the author’s belief that a zeal for souls, however necessary, is not the sufficient condition. Have there not been devout saints in every age, numerous enough to carry on a revival? Twelve such persons are plenty. What distinguishes the arid ages from the period of the Reformation, when nations were moved as they had not been since Paul preached in Ephesus, Corinth, and Rome, is the latter’s fullness of knowledge of God’s Word. To echo an early Reformation thought, when the plough man and the garage attendant know the Bible as well as the theologian does, and know it better than some contemporary theologians, then the desired awakening shall have already occurred.*********And we know that the Son of God is come, and hath given us an understanding, that we may know him that is true, and we are in him that is true, in his Son Jesus Christ. This is the true God, and eternal life.

Cell Death & Differentiation, doi:10.1038/s41418-021-00871-3

Religious pluralism is the greatest challenge facing Christianity in today's Western culture. The belief that Christ is the only way to God is being challenged and, increasingly, Christianity is seen as just one among many valid paths to God. In this book four perspectives are presented by their major proponents.

Background Hereditary angioedema is a rare and potentially life-threatening genetic disease that is associated with kallikrein–kinin system dysregulation. Garadacimab (CSL312), a novel, fully-human monoclonal antibody that inhibits activated factor XII (FXIIa), is being studied for the prevention of hereditary angioedema attacks. The aim of this study was to evaluate the efficacy and safety of once-monthly subcutaneous administrations of garadacimab as prophylaxis for hereditary angioedema. Methods VANGUARD was a pivotal, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial that recruited patients (aged ≥12 years) with type I or type II hereditary angioedema across seven countries (Canada, Germany, Hungary, Israel, Japan, the Netherlands, and the USA). Eligible patients were randomly assigned (3:2) to receive garadacimab or placebo for 6 months (182 days) by an interactive response technology (IRT) system. Randomisation was stratified by age (≤17 years vs >17 years) and baseline attack rate (1 to <3 attacks per month vs ≥3 attacks per month) for the adult group. The randomisation list and code were kept by the IRT provider during the study, with no access by site staff and funding representatives. All patients and investigational site staff, and representatives from the funder (or their delegates) with direct interaction with the study sites or patients, were masked to treatment assignment in a double-blind fashion. Randomly assigned patients received a 400-mg loading dose of subcutaneous garadacimab as two 200-mg injections or volume-matched placebo on day 1 of the treatment period, followed by five additional self-administered (or caregiver-administered) monthly doses of 200-mg subcutaneous garadacimab or volume-matched placebo. The primary endpoint was the investigator-assessed time-normalised number of hereditary angioedema attacks (number of hereditary angioedema attacks per month) during the 6-month treatment period (day 1 to day 182). Safety was evaluated in patients who received at least one dose of garadacimab or placebo. The study is registered with the EU Clinical Trials Register, 2020-000570-25 and ClinicalTrials.gov, NCT04656418. Findings Between Jan 27, 2021, and June 7, 2022, we screened 80 patients, 76 of whom were eligible to enter the run-in period of the study. Of 65 eligible patients with type I or type II hereditary angioedema, 39 were randomly assigned to garadacimab and 26 to placebo. One patient was randomly assigned in error and did not enter the treatment period (no dose of study drug received), resulting in 39 patients assigned to garadacimab and 25 patients assigned to placebo being included. 38 (59%) of 64 participants were female and 26 (41%) were male. 55 (86%) of 64 participants were White, six (9%) were Asian (Japanese), one (2%) was Black or African American, one (2%) was Native Hawaiian or Other Pacific Islander, and one (2%) was listed as other. During the 6-month treatment period (day 1 to day 182), the mean number of investigator-confirmed hereditary angioedema attacks per month was significantly lower in the garadacimab group (0·27, 95% CI 0·05 to 0·49) than in the placebo group (2·01, 1·44 to 2·57; p<0·0001), corresponding to a percentage difference in means of –87% (95% CI –96 to –58; p<0·0001). The median number of hereditary angioedema attacks per month was 0 (IQR 0·00–0·31) for garadacimab and 1·35 (1·00–3·20) for placebo. The most common treatment-emergent adverse events were upper-respiratory tract infections, nasopharyngitis, and headaches. FXIIa inhibition was not associated with an increased risk of bleeding or thromboembolic events. Interpretation Monthly garadacimab administration significantly reduced hereditary angioedema attacks in patients aged 12 years and older compared with placebo and had a favourable safety profile. Our results support the use of garadacimab as a potential prophylactic therapy for the treatment of hereditary angioedema in adolescents and adults. Funding CSL Behring.

Bibliography : p. 209-218. *** Includes index, 6

The essays in "Archaeology and History in Medieval and Post-Medieval Greece" honor the contributions of Timothy E. Gregory by providing a broad perspective on the study of Greece after the end of Antiquity. The essays in this volume highlight the wide influence of Gregory's intellectual travels by bringing together anthropologists, art historians, archaeologists, historians, and philologists who reflect the influence of his thought and interests. In doing so, this volume juxtaposes studies of archaeological method and analysis and conceives of historical interpretation as a product of methodological self-awareness.The papers here demonstrate how analysis informed by multiple disciplines sheds new light on such venerable topics as the end of Antiquity, the so-called Byzantine Dark Ages, the contours of the emerging Byzantine civilization, as well as the complex character of identity in post-Medieval Greece. More broadly, this volume shows how the study of the material culture of Medieval and Post-Medieval Greece has made significant contributions to both the larger archaeological and historical discourse.The essays in this volume are organized under three headings: Archaeology and Method, the Archaeology of Identity, and the Changing Landscape, which highlight three main focuses of Gregory's research. Each essay interlaces new analyses with the contributions Gregory has made to our understanding of Medieval and Post-Medieval Greece. Read together these essays present not only new research in the field but also put on display the wide panorama of methods and questions developed of interest to scholars today.

xxiii, 316 pages ; 24 cm The Second Temple period is an era that marked a virtual explosion in the world of literature, with the creation, redaction, interpretation, and transmission of Jewish texts that represented diverse languages and ideologies. The creation of many of these writings coincided with the growth of the Jewish community beyond the borders of Israel; therefore, among those for whom the Temple played a diminishing role. The transition period from Temple to texts was accompanied by conflicting interpretations about the role of the Temple as well as diverse theological understandings about God and the Jewish people. Drawing on the expertise of leading specialists in Second Temple Judaism, Temple, Texts, and Traditions explores the rich traditions of the Jewish people as they were expressed and interpreted in their writings in that period, which included writings that later became recognized as Scriptures Includes bibliographical references and indexes The boundaries of translation / Anthony Gelston -- What will happen to the serpent? unending struggle, hermeneutics, and the interpretation of Genesis 3.15 / R.W.L. Moberly -- Reconstructing Tobit 13.6-10 / Stuart Weeks -- Jewish worship amid greeks: the lexical context of the old greek psalter / James K. Aitken -- Rabbinic and patristic Bible exegesis as intertexts: towards a theory of comparative Midrash / Philip S. Alexander -- The Paraclete / Margaret Barker -- The zeal of readers in defence and in dissent: Phinehas' Spear, The Covenant of Peace, and the politics of hermeneutics / Richard S. Briggs -- Reading, searching and blessing: a functional approach to scriptural interpretation in the -- George J. Brooks / Joseph as exemplar of wisdom: hidden allusion in Sirach 21.11-21 / Jeremy Corley -- Samples of variant readings in the armenian proverbs: a comparison with the hexaplaric text and the Peshitta / Lorenzo Cuppi -- The greek translations of Daniel 4-6 / R. Timothy Mclay -- A glasgow octateuch and a leiden psalter, two Old Testament manuscripts formerly belonging to Dr John Clement (CA. 1500-1572): history and hypothesis / J. Lionel North -- Observations on the structure and literary fabric of the temple scroll / Alex Samely -- The sons of Joseph in 1 Chronicles 5.1-2 and in early samaritan tradition / H.G.M. Williamson

Management consultants of various kinds play an important role in the world of business, and other organizations. This Handbook provides a comprehensive overview of research and thinking on the role, history, and function of management consultants.

Management consultants of various kinds play an important role in the world of business, and other organizations. This Handbook provides a comprehensive overview of research and thinking on the role, history, and function of management consultants.

Cover 1 Half Title 2 Also Available from Bloomsbury 3 Title 4 Copyright 5 Dedication 6 Contents 8 List of illustrations 9 Acknowledgements 10 Preface 11 CHAPTER ONE The Anthropocene – questions of definition 14 The overview effect 16 ‘We are as Gods? No, for we have created the power but not the mind’18 19 A global imaginary? 29 Summary 35 CHAPTER TWO Imaging and imagining the whole Earth: The terrestrial as norm 42 Implications 49 The phantasm of normality: Terrestriality and John Keats’s ‘To Autumn’ 52 CHAPTER THREE Emergent unreadability: Rereading a lyric by Gary Snyder 60 Historical contextualizing 64 Spatial containment: Methodological nationalism 67 Conceptions of nature and the transcorporeal 69 Biological contexts: The fire ape 72 Emergence and anachrony 74 Conclusion 79 CHAPTER FOUR Scale framing 84 Scale effects 85 Scale framing 86 Scale framing as miniaturization: Two cases 88 Overpopulation 93 Literary representations of overpopulation 100 CHAPTER FIVE Scale framing: A reading 110 ‘Petro-minimalist realism’ 117 Some implications 120 Ecophobia? 122 CHAPTER SIX Postcolonial ecocriticism and de-humanizing reading: An Australian test case 128 Setting up a reading experiment 130 First reading 132 Second reading 136 Conclusion 142 CHAPTER SEVEN Anthropocene disorder 152 CHAPTER EIGHT Denial: A reading 172 CHAPTER NINE The tragedy that climate change is not ‘interesting’ 188 The Anthropocene as threshold to a new phase of art? 196 Some questions 200 Conclusion 208 Bibliography 212 Index 224

Dossier de traducciones a partir de una selección y traducción de ensayos publicados en Critical Climate Change, serie de libros editada por Tom Cohen y Claire Colebrook para Open Humanities Press, que reflexionan sobre el rol de los estudios críticos sobre el medio ambiente en el presente.

"The global pandemic threw hundreds of millions of people out of work, sparking career crises worldwide. The revised edition of the 100,000 selling Business Model You now adds powerful new material for the 40 million U.S. workers in healthcare, education, government, the military, and nonprofit/social enterprises who do not consider their professions as "businesses" and who are typically averse to business jargon. It uses the same logic as the Personal Business Model but with modified language, including the Service Model Canvas. Business Model You 2e will address dramatic workscape changes with new tools including the Three Career Questions, Your Professional Identity, "Your Key Roles & Relationships" How to Decide Whether to Work for Yourself, and Digital Tools for Everyone. Cases will be drawn from mainstream sectors such as healthcare, education, and government, avoiding "glamour" and outlier occupations covered in the first edition"-- Provided by publisher

Since the publication of his mammoth work, Being and Time, Martin Heidegger has remained one of the most influential figures in contemporary thought, and is a key influence for modern literary and cultural theory. This guidebook provides an ideal entry-point for readers new to Heidegger, outlining such issues and concepts as: the limits of 'theory' the history of being the origin of the work of art language the literary work poetry and the political Heidegger's involvement with Nazism. Fully updated throughout and featuring a new section on enviromental thought and ecocriticism, this guidebook clearly and concisely introduces Heidegger's crucial work relating to art, language and poetry, and outlines his continuing influence on critical theory. Literary Criticism,General,Philosophy

Contains condensed versions of: *Every Living Thing* - by James Herriot *All Around the Town* - by Mary Higgins Clark *Colony* - by Anne Rivers Siddons *Death Penalty* - by William Coughlin

This paper offers an overview of the chameleonic nature of overpopulation as an environmental issue, and of the relative evasion of population as an issue in ecocriticism and elsewhere: the very multiplicity of environmental factors means that population pressure can always seem to be finessed as “really” something else. Overpopulation looks drastically different as an issue, depending on whether it is considered at the level of the nation state, that of individual right, or as a global phenomenon. Finally, the chameleonic nature of overpopulation poses intractable challenges to literary representation, since it resists representation at the scalar norms of realism.

Studies of medieval Biblical interpretation usually focus on the printed literature, neglecting the vast majority of relevant works. Timothy Bellamah offers a groundbreaking examination of the exegesis of William of Alton, a thirteenth-century Dominican regent master at Paris whose commentaries have never previously appeared in print. As a near contemporary of Hugh of St. Cher, Bonaventure, Albert the Great, and Thomas Aquinas, William was an important representative of university exegesis at a time of rapidly changing methods and remarkable intellectual development. His commentaries are valuable resources for understanding Biblical study of the thirteenth century, in the schoolroom and in the pulpit. Yet study of William's work has been impeded by the dubious authenticity of numerous commentaries questionably attributed to him over the centuries. Bellamah addresses these complex problems by unearthing evidence of authorship in each commentary's style and methodology. This inquiry employs the traits of William's commentaries as criteria for constituting a list of works that can be reliably attributed to him, which, in turn, provides a crucial basis for studying his exegesis. William was a man of his time, but even more than his contemporaries he was deeply interested in history and the literal sense, which he understood to be the intention of Scripture's authors, divine and human. He took a keen interest in Biblical history and put to use a wide array of procedures for textual, linguistic, and rhetorical analysis. At the same time, he remained aware of the spiritual senses and the diverse elements of the exegetical and theological tradition in which he stood.