<p><P>Residues of drugs and chemicals in edible tissues of food-producing animals are a major public health concern. Until now, information on applications of pharmacokinetic principles to drug and chemical residue avoidance has been spread throughout literature. For the first time, this handbook brings this information together in a convenient and concise volume.<br>For easier reference, text is divided into three parts: physicochemical constants and chemical structures, legal tissue tolerances, and pharmacokinetic parameters derived from open literature. This is the only publication that offers all this information in a single source. For fast access, numerous tables present valuable pharmacokinetic data for drugs in serum, plasma, or blood and in other matrices. The authors include their own previously unpublished pharmacokinetic parameters, results of statistical analyses performed on time/concentration data tabulated in the primary sources. Helpful appendices contain FDA approved tolerances and action levels as well as chemical structures and physicochemical properties. This is an essential handbook for veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.</p> <h3>Gavin L. Meerdink</h3> <p>This is the third in a series of handbooks dedicated to the application of pharmacokinetic principles to drug and chemical residue avoidance in animal source foods. Volume I contains information on antimicrobial drugs; volume 2 includes therapeutic and growth promotion agents; and this volume completes the series with information on pesticides and environmental contaminants of residue concern. The primary purpose is to tabulate pharmacokinetic data related to pesticides and environmental contaminants. These data are essential in understanding the problems of contamination and residues in the field and in designing research studies to help eliminate the problem. The information presented will be of use to veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety. These handbooks are an outgrowth of the Food Animal Residue Avoidance Databank (FARAD), which was established by these authors under the auspices of the U.S. Department of Agriculture Residue Avoidance Program. The authors provide concise introductions to matters of metabolism and pharmacokinetics and clearly orient the reader in the use of the chapters and tables. The information is conveniently categorized into three classes: physicochemical constants and structures, legal tissue tolerances, and pharmacokinetic parameters. The table of contents, index, and reference enumeration allow for rapid location of information. This is the only publication in which all of this information is available in a single source. Much of the pharmacokinetic parameters, performed by the authors on time/concentration data tabulated in the primary sources, are notpublished elsewhere. This is a welcome addition to the first two volumes and essential to the concerns of animal source food safety.</p>
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